Title-Inflammatory Signaling Pathways in Allergic and Infection-Associated Lung Diseases
Round 1
Reviewer 1 Report
This review article by Upadhyay et al. is well-written and discusses a number of subjects pertinent to the inflammatory signaling pathways in allergic and infection-asssociated lung diseases. Most of the subjects are covered to a sufficient degree and only minor concerns need to be addressed by the authors.
Firstly, the authors need to be consistent with the use of abbreviations during first appearance throughout the manuscript. One such example is located in section 3.1 where "TLR and NLR signaling..." is mentioned first and a few lines later the authors write "Another set of PRRs called NOD-like receptors (NLRs),...". Other examples are Haemagglutinin, which is abbreviated in Table 1 (page 5) and omitted in section 3.2 (page 4) and Janus Kinase (JAK) which is abbreviated on pages 5 and 10!
Secondly, the authors should avoid (a) using incomplete descriptions like in the case of NLRs in section 3.1 where they state "Another set of PRRs called NOD-like receptors (NLRs), NOD1 and NOD2, are cytosolic and bind to a specific component of bacteria..." and (b) omitting references like in section 6 where the sentence "In contrast, some other cytokines repress the hypersensitive inflammatory process, and such cytokines may have a therapeutic perspective" introduces therapeutic targets which remain nameless ("other") and unreferenced.
Lastly, there are a few awkward phrasings that need to be corrected.
Section 4.1: ... and contributes to the pathophysiology of allergic inflammation Asthma[73].
Section 4.2: ...infiltration of lymphocytes and mast cells high serum IgE levels...
...The Lyn activation of leads to intracellular calcium efflux....
Section 8: ...an excessive amount of infiltration immune cells stimulated eosinophils...
Additionally, in section 4.1 I believe that by writing "Alternaria Alternaria" the authors mean Alternaria alternata.
Author Response
Reviewer 1.
1) Firstly, the authors need to be consistent with the use of abbreviations during first appearance throughout the manuscript.
Response: We have made corrections to be consistent with the use of abbreviations.
2) Secondly, the authors should avoid (a) using incomplete descriptions like in the case of NLRs in section 3.1 where they state "Another set of PRRs called NOD-like receptors (NLRs), NOD1 and NOD2, are cytosolic and bind to a specific component of bacteria..." and (b) omitting references like in section 6 where the sentence "In contrast, some other cytokines repress the hypersensitive inflammatory process, and such cytokines may have a therapeutic perspective" introduces therapeutic targets which remain nameless ("other") and unreferenced.
Response: We have made corrections in the main text to be consistent with complete sentence formations.
Lastly, there are a few awkward phrasings that need to be corrected.
3) Section 4.1: ... and contributes to the pathophysiology of allergic inflammation Asthma[73].
Response: Thank you, the sentence/statement has been corrected now.
4) Section 4.2: ...infiltration of lymphocytes and mast cells high serum IgE levels...
Response: We have corrected the sentence.
5) The Lyn activation of leads to intracellular calcium efflux....
Response: We have corrected the sentence.
6) Section 8: ...an excessive amount of infiltration immune cells stimulated eosinophils...
Response: We have corrected the sentence.
7) Additionally, in section 4.1 I believe that by writing "Alternaria Alternaria" the authors mean Alternaria alternata.
Response: We have made the correction.
Reviewer 2 Report
This is a very well-researched and written review article and provides a lot of knowledge to the related field. Although authors have tried to provide a lot of information, a few things need to be addressed-
- Authors should write the different sections for allergic asthma and hypersensitivity pneumonitis (HP) and provide a proper distinguishment between them.
- The authors should have included a section for lung inflammation and receptor signaling pathways in response to pollens and food allergens as they also cause allergic reactions and lung inflammation.
- Authors should also write a section for T-regulatory cells and mechanisms to explain how they are important in regulating allergic diseases.
- Please provide the abbreviation list. For example, authors have not written full forms of GM-CSF, MIP-2, and KC.
- Botanical names should be in Italics and species names should start with a small letter. For example- in the ILCs section- authors should write “Alternaria alternata” instead of Alternaria Alternaria.
Author Response
Reviewer 2
- Authors should write the different sections for allergic asthma and hypersensitivity pneumonitis (HP) and provide a proper distinguishment between them.
Response: We have modified the main text to be more clear now.
- The authors should have included a section for lung inflammation and receptor signaling pathways in response to pollens and food allergens as they also cause allergic reactions and lung inflammation.
Response: Thank you for suggestion; however, we did not include information on lung inflammation and receptor signaling pathways in response to pollens and food allergens in our revised manuscript due to time constraints.
- Authors should also write a section for T-regulatory cells and mechanisms to explain how they are important in regulating allergic diseases.
Response: Thank you for the suggestion; however, we feel that extensive information is already available on T-regulatory cells and mechanisms regarding allergic diseases. Therefore, a small section written in our current article on the T-reg cells will not benefit the readers.
- Please provide the abbreviation list. For example, authors have not written full forms of GM-CSF, MIP-2, and KC.
Response: Full forms of GM-CSF, MIP-2, KC, and all other abbreviations are provided now.
- Botanical names should be in Italics and species names should start with a small letter. For example- in the ILCs section- authors should write “Alternaria alternata”instead of Alternaria Alternaria.
Response: Corrections made now.
