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Recent Advances of Cellulase Immobilization onto Magnetic Nanoparticles: An Update Review

Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran 1411713137, Iran
Department of Biology, Faculty of Sciences, University of Payame Noor, Tehran 19395-3697, Iran
Department of Medical Nanotechnology, Applied Biophotonics Research Center, Science and Research Branch, Islamic Azad University, Tehran 1477893855, Iran
Zar Center, University of Applied Science and Technology (UAST), Karaj 1599665111, Iran
Author to whom correspondence should be addressed.
Magnetochemistry 2019, 5(2), 36;
Received: 25 April 2019 / Revised: 2 June 2019 / Accepted: 4 June 2019 / Published: 10 June 2019
(This article belongs to the Special Issue Magnetic Nanoparticles)
Cellulosic enzymes, including cellulase, play an important role in biotechnological processes in the fields of food, cosmetics, detergents, pulp, paper, and related industries. Low thermal and storage stability of cellulase, presence of impurities, enzyme leakage, and reusability pose great challenges in all these processes. These challenges can be overcome via enzyme immobilization methods. In recent years, cellulase immobilization onto nanomaterials became the focus of research attention owing to the surface features of these materials. However, the application of these nanomaterials is limited due to the efficacy of their recovery process. The application of magnetic nanoparticles (MNPs) was suggested as a solution to this problem since they can be easily removed from the reaction mixture by applying an external magnet. Recently, MNPs were extensively employed for enzyme immobilization owing to their low toxicity and various practical advantages. In the present review, recent advances in cellulase immobilization onto functionalized MNPs is summarized. Finally, we discuss enhanced enzyme reusability, activity, and stability, as well as improved enzyme recovery. Enzyme immobilization techniques offer promising potential for industrial applications. View Full-Text
Keywords: cellulase immobilization; magnetic nanoparticles; stability; functionalized nanoparticles cellulase immobilization; magnetic nanoparticles; stability; functionalized nanoparticles
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MDPI and ACS Style

Khoshnevisan, K.; Poorakbar, E.; Baharifar, H.; Barkhi, M. Recent Advances of Cellulase Immobilization onto Magnetic Nanoparticles: An Update Review. Magnetochemistry 2019, 5, 36.

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