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Volume 9
Issue 2
10.3390/ncrna9020023
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Review

CircRNAs and RNA-Binding Proteins Involved in the Pathogenesis of Cancers or Central Nervous System Disorders

by
Yuka Ikeda
,
Sae Morikawa
,
Moeka Nakashima
,
Sayuri Yoshikawa
,
Kurumi Taniguchi
,
Haruka Sawamura
,
Naoko Suga
,
Ai Tsuji
and
Satoru Matsuda
*
Department of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, Japan
*
Author to whom correspondence should be addressed.
Non-Coding RNA 2023, 9(2), 23; https://doi.org/10.3390/ncrna9020023
Submission received: 27 February 2023 / Revised: 21 March 2023 / Accepted: 29 March 2023 / Published: 31 March 2023
(This article belongs to the Special Issue ncRNAs to Target Molecular Pathways)
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Abstract

Circular RNAs (circRNAs), a newly recognized group of noncoding RNA transcripts, have established widespread attention due to their regulatory role in cell signaling. They are covalently closed noncoding RNAs that form a loop, and are typically generated during the splicing of precursor RNAs. CircRNAs are key post-transcriptional and post-translational regulators of gene expression programs that might influence cellular response and/or function. In particular, circRNAs have been considered to function as sponges of specific miRNA, regulating cellular processes at the post-transcription stage. Accumulating evidence has shown that the aberrant expression of circRNAs could play a key role in the pathogenesis of several diseases. Notably, circRNAs, microRNAs, and several RNA-binding proteins, including the antiproliferative (APRO) family proteins, could be indispensable gene modulators, which might be strongly linked to the occurrence of diseases. In addition, circRNAs have attracted general interest for their stability, abundance in the brain, and their capability to cross the blood–brain barrier. Here, we present the current findings and theragnostic potentials of circRNAs in several diseases. With this, we aim to provide new insights to support the development of novel diagnostic and/or therapeutic strategies for these diseases.
Keywords: circular RNA; APRO family protein; RNA binding protein; translational regulator; poly(A)-binding protein circular RNA; APRO family protein; RNA binding protein; translational regulator; poly(A)-binding protein

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MDPI and ACS Style

Ikeda, Y.; Morikawa, S.; Nakashima, M.; Yoshikawa, S.; Taniguchi, K.; Sawamura, H.; Suga, N.; Tsuji, A.; Matsuda, S. CircRNAs and RNA-Binding Proteins Involved in the Pathogenesis of Cancers or Central Nervous System Disorders. Non-Coding RNA 2023, 9, 23. https://doi.org/10.3390/ncrna9020023

AMA Style

Ikeda Y, Morikawa S, Nakashima M, Yoshikawa S, Taniguchi K, Sawamura H, Suga N, Tsuji A, Matsuda S. CircRNAs and RNA-Binding Proteins Involved in the Pathogenesis of Cancers or Central Nervous System Disorders. Non-Coding RNA. 2023; 9(2):23. https://doi.org/10.3390/ncrna9020023

Chicago/Turabian Style

Ikeda, Yuka, Sae Morikawa, Moeka Nakashima, Sayuri Yoshikawa, Kurumi Taniguchi, Haruka Sawamura, Naoko Suga, Ai Tsuji, and Satoru Matsuda. 2023. "CircRNAs and RNA-Binding Proteins Involved in the Pathogenesis of Cancers or Central Nervous System Disorders" Non-Coding RNA 9, no. 2: 23. https://doi.org/10.3390/ncrna9020023

APA Style

Ikeda, Y., Morikawa, S., Nakashima, M., Yoshikawa, S., Taniguchi, K., Sawamura, H., Suga, N., Tsuji, A., & Matsuda, S. (2023). CircRNAs and RNA-Binding Proteins Involved in the Pathogenesis of Cancers or Central Nervous System Disorders. Non-Coding RNA, 9(2), 23. https://doi.org/10.3390/ncrna9020023

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