Emerging Role of Circular RNA–Protein Interactions
Abstract
:1. Introduction
2. CircRNA Biogenesis and Regulatory RBPs
3. The Functions of circRNAs
4. The Function of circRNA–Protein Interactions
4.1. Cancer Progression and Apoptosis
4.2. Cell Proliferation and Senescence
4.3. Energy Metabolism
4.4. Translation Regulation
4.5. Cell Morphology and Differentiation
4.6. Autophagy and Cell Death
5. Approaches to Analyze circRNA–Protein Interactions
6. Concluding Remarks
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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RBP(s) | Cell Type/Tissue | Regulated circRNA(s) | Reference |
---|---|---|---|
MBNL1 | Drosophila S2 and HEK293T | CircMbl | [23] |
QKI | Epithelial-mesenchymal transition | CircSMARCA5 | [24] |
Cardiac tissue | CircRNA from titin and striatin | [25] | |
HnRNPs and SR Proteins | S2 and DL1 cell culture lines of Drosophila | Laccase 2 circRNA | [26] |
RBM20 | Cardiac muscle tissue | CircRNAs from I-band of titin gene | [27] |
DHX9 | Human embryonic stem cells | CircRNAs with Alu element in the flanking introns | [28] |
Colorectal cancer | CircCCDC66 | [29] | |
Sam68 | HEK293T | SMN circRNA | [30] |
NOVA2 | Brain cortex | CircEfnb2 | [31] |
SFPQ | HepG2 and K562 | DALI circRNAs | [32] |
NF90/NF110 | HeLa | CircDHX34 | [33] |
HNRNPL | Prostate Cancer LNCap | More than 200 circRNAs | [34] |
FUS | N2a | More than 200 circRNAs | [35] |
ESRP1 | Human embryonic stem | CircBIRC6 | [36] |
TNRC6A | Lung cancer cell | Circ0006916 | [37] |
RBM3 | hepatocellular carcinoma | SCD-circRNA2 | [38] |
circRNA | Cell/Tissue, Localization | Cellular Localization | Interacting Proteins | Activity | Ref(s). |
---|---|---|---|---|---|
CircZKSCAN1 | HCC | Cytoplasm | FMRP | Cancer cell stemness↑ | [51] |
CircSMARCA5 | Glioblastoma | - | SRSF1 | Angiogenesis and cell migration↓ | [52,53] |
CircE2F2 | Ovarian cancer | Cytoplasm | HuR | Cell migration↑ | [54] |
CircFECR1 | Breast cancer tissue | Nucleus and cytoplasm | TET1 demethylase | Metastasis↑ | [55] |
CircNSUN2 | Colorectal cancer | Cytoplasm | YTHDC1 | Metastasis↑ | [56] |
CircANRIL | Atherosclerosis | - | PES1 | Apoptosis↑ | [57] |
CircAmotl1 | Heart | - | AKT1 | Apoptosis↓ | [58] |
CircDNMT1 | Breast cancer | Nucleus | AUF1 | Apoptosis↓ | [59] |
CircDONSON | Gastric cancer | - | NURF complex | Apoptosis↓ | [60] |
CircRHOT1 | HCC | Nucleus | TIP60 | Apoptosis↓ | [61] |
CircE2F3 | Retinoblastoma | Cytoplasm | HNRNPK | Apoptosis↓ | [62] |
CircFoxo3 | Breast cancer | Cytoplasm | p53, MDM2 | Apoptosis↑ | [63] |
CircFoxo3 | Cardia fibroblast | Cytoplasm | p21, CDK2 | Cell proliferation↓ | [44] |
CircFoxo3 | Heart | Cytoplasm | ID1, E2F1, HIF1α, FAK | Replicative senescence↑ | [64] |
CircBACH1 | HCC | Nucleus and cytoplasm | HuR | Cell proliferation↑ | [65] |
CircCcnb1 | Breast cancer | Nucleus | H2AX | Cell proliferation↑ | [66,67] |
CircMTO1 | Breast cancer | Cytoplasm | TRAF4 | Cell proliferation↓ | [68] |
CircPCNX | HeLa | Cytoplasm | AUF1 | Cell proliferation↓ | [69] |
CircCUX1 | Neuroblastoma | - | EWSR1 | Cell proliferation↑ | [70] |
CircACC1 | Colorectal cancer | Cytoplasm | AMPK | Glycolysis and fatty acid oxidation↑ | [71] |
Ci-Ins2 | Pancreatic β-cells | Nucleus | TARDBP | Insulin secretion↑ | [72] |
CircPABPN1 | HeLa | - | HuR | PABPN1 translation↓ | [43] |
CircAGO2 | Gastric cancer | Cytoplasm | HuR | Binding of RISC to mRNAs↓ | [73] |
CircHECTD1 | Alveolar macrophage | Cytoplasm | ZC3HI2A | Macrophage differentiation↑ | [74] |
CircSamd4 | C2C12 myoblast | Cytoplasm | PUR proteins | Myogenesis↑ | [75] |
CircYap | Cardiac fibrosis | Nucleus | TPM4 and ACTG | Actin polymerization↓ | [76] |
CircARSP91 | HCC | - | ULBP1 | Cell death by NK cells↑ | [77,78] |
Circ0005276 | Prostate cancer | - | FUS | Autophagy↓ | [79] |
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Das, A.; Sinha, T.; Shyamal, S.; Panda, A.C. Emerging Role of Circular RNA–Protein Interactions. Non-Coding RNA 2021, 7, 48. https://doi.org/10.3390/ncrna7030048
Das A, Sinha T, Shyamal S, Panda AC. Emerging Role of Circular RNA–Protein Interactions. Non-Coding RNA. 2021; 7(3):48. https://doi.org/10.3390/ncrna7030048
Chicago/Turabian StyleDas, Arundhati, Tanvi Sinha, Sharmishtha Shyamal, and Amaresh Chandra Panda. 2021. "Emerging Role of Circular RNA–Protein Interactions" Non-Coding RNA 7, no. 3: 48. https://doi.org/10.3390/ncrna7030048
APA StyleDas, A., Sinha, T., Shyamal, S., & Panda, A. C. (2021). Emerging Role of Circular RNA–Protein Interactions. Non-Coding RNA, 7(3), 48. https://doi.org/10.3390/ncrna7030048