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Non-Coding Variants in Cancer: Mechanistic Insights and Clinical Potential for Personalized Medicine

by 1,†, 1,† and 1,2,*
1
Department of Biochemistry and Biotechnology, University of Thessaly, Biopolis, 41500 Larissa, Greece
2
Institute for Fundamental Biomedical Research, B.S.R.C “Alexander Fleming”, 34 Fleming Str., 16672 Vari, Greece
*
Author to whom correspondence should be addressed.
These authors contributed equally to this manuscript.
Academic Editor: George A. Calin
Non-Coding RNA 2021, 7(3), 47; https://doi.org/10.3390/ncrna7030047
Received: 28 June 2021 / Revised: 26 July 2021 / Accepted: 1 August 2021 / Published: 2 August 2021
(This article belongs to the Collection Feature Papers in Non-coding RNA)
The cancer genome is characterized by extensive variability, in the form of Single Nucleotide Polymorphisms (SNPs) or structural variations such as Copy Number Alterations (CNAs) across wider genomic areas. At the molecular level, most SNPs and/or CNAs reside in non-coding sequences, ultimately affecting the regulation of oncogenes and/or tumor-suppressors in a cancer-specific manner. Notably, inherited non-coding variants can predispose for cancer decades prior to disease onset. Furthermore, accumulation of additional non-coding driver mutations during progression of the disease, gives rise to genomic instability, acting as the driving force of neoplastic development and malignant evolution. Therefore, detection and characterization of such mutations can improve risk assessment for healthy carriers and expand the diagnostic and therapeutic toolbox for the patient. This review focuses on functional variants that reside in transcribed or not transcribed non-coding regions of the cancer genome and presents a collection of appropriate state-of-the-art methodologies to study them. View Full-Text
Keywords: cancer; non-coding variability; SNPs; CNVs; lncRNAs; miRNAs cancer; non-coding variability; SNPs; CNVs; lncRNAs; miRNAs
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MDPI and ACS Style

Lange, M.; Begolli, R.; Giakountis, A. Non-Coding Variants in Cancer: Mechanistic Insights and Clinical Potential for Personalized Medicine. Non-Coding RNA 2021, 7, 47. https://doi.org/10.3390/ncrna7030047

AMA Style

Lange M, Begolli R, Giakountis A. Non-Coding Variants in Cancer: Mechanistic Insights and Clinical Potential for Personalized Medicine. Non-Coding RNA. 2021; 7(3):47. https://doi.org/10.3390/ncrna7030047

Chicago/Turabian Style

Lange, Marios, Rodiola Begolli, and Antonis Giakountis. 2021. "Non-Coding Variants in Cancer: Mechanistic Insights and Clinical Potential for Personalized Medicine" Non-Coding RNA 7, no. 3: 47. https://doi.org/10.3390/ncrna7030047

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