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Nanoliposomal Delivery of MicroRNA-203 Suppresses Migration of Triple-Negative Breast Cancer through Distinct Target Suppression

1
Department of Biology, Baylor University, Waco, TX 76706, USA
2
Department of Environmental Science, Baylor University, Waco, TX 76706, USA
*
Author to whom correspondence should be addressed.
Academic Editor: George A. Calin
Non-Coding RNA 2021, 7(3), 45; https://doi.org/10.3390/ncrna7030045
Received: 11 May 2021 / Revised: 14 July 2021 / Accepted: 21 July 2021 / Published: 27 July 2021
Triple-negative breast cancers affect thousands of women in the United States and disproportionately drive mortality from breast cancer. MicroRNAs are small, non-coding RNAs that negatively regulate gene expression post-transcriptionally by inhibiting target mRNA translation or by promoting mRNA degradation. We have identified that miRNA-203, silenced by epithelial–mesenchymal transition (EMT), is a tumor suppressor and can promote differentiation of breast cancer stem cells. In this study, we tested the ability of liposomal delivery of miR-203 to reverse aspects of breast cancer pathogenesis using breast cancer and EMT cell lines. We show that translationally relevant methods for increasing miR-203 abundance within a target tissue affects cellular properties associated with cancer progression. While stable miR-203 expression suppresses LASP1 and survivin, nanoliposomal delivery suppresses BMI1, indicating that suppression of distinct mRNA target profiles can lead to loss of cancer cell migration. View Full-Text
Keywords: microRNA-203; EMT; nanoliposome; nanoparticle; microRNA; breast cancer microRNA-203; EMT; nanoliposome; nanoparticle; microRNA; breast cancer
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MDPI and ACS Style

Song, S.; Johnson, K.S.; Lujan, H.; Pradhan, S.H.; Sayes, C.M.; Taube, J.H. Nanoliposomal Delivery of MicroRNA-203 Suppresses Migration of Triple-Negative Breast Cancer through Distinct Target Suppression. Non-Coding RNA 2021, 7, 45. https://doi.org/10.3390/ncrna7030045

AMA Style

Song S, Johnson KS, Lujan H, Pradhan SH, Sayes CM, Taube JH. Nanoliposomal Delivery of MicroRNA-203 Suppresses Migration of Triple-Negative Breast Cancer through Distinct Target Suppression. Non-Coding RNA. 2021; 7(3):45. https://doi.org/10.3390/ncrna7030045

Chicago/Turabian Style

Song, Shuxuan, Kelsey S. Johnson, Henry Lujan, Sahar H. Pradhan, Christie M. Sayes, and Joseph H. Taube. 2021. "Nanoliposomal Delivery of MicroRNA-203 Suppresses Migration of Triple-Negative Breast Cancer through Distinct Target Suppression" Non-Coding RNA 7, no. 3: 45. https://doi.org/10.3390/ncrna7030045

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