Functional Role of miR-155 in the Pathogenesis of Diabetes Mellitus and Its Complications
1
Department of Medicine, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, New York, NY 10461, USA
2
Department of Molecular Pharmacology, Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA
3
International Translational Research and Medical Education Consortium (ITME), Department of Advanced Biomedical Science, “Federico II” University, 80131 Naples, Italy
4
Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: George A Calin
Non-Coding RNA 2021, 7(3), 39; https://doi.org/10.3390/ncrna7030039
Received: 31 May 2021
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Revised: 30 June 2021
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Accepted: 3 July 2021
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Published: 7 July 2021
(This article belongs to the Special Issue Non-coding RNA: 5th Anniversary)
Substantial evidence indicates that microRNA-155 (miR-155) plays a crucial role in the pathogenesis of diabetes mellitus (DM) and its complications. A number of clinical studies reported low serum levels of miR-155 in patients with type 2 diabetes (T2D). Preclinical studies revealed that miR-155 partakes in the phenotypic switch of cells within the islets of Langerhans under metabolic stress. Moreover, miR-155 was shown to regulate insulin sensitivity in liver, adipose tissue, and skeletal muscle. Dysregulation of miR-155 expression was also shown to predict the development of nephropathy, neuropathy, and retinopathy in DM. Here, we systematically describe the reports investigating the role of miR-155 in DM and its complications. We also discuss the recent results from in vivo and in vitro models of type 1 diabetes (T1D) and T2D, discussing the differences between clinical and preclinical studies and shedding light on the molecular pathways mediated by miR-155 in different tissues affected by DM.
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Keywords:
β-cells; diabetes; epigenetics; inflammation; insulin; islets; MafB; metabolic syndrome; micro-RNA; miR-155; NF-κB; NRF2; PBMC
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MDPI and ACS Style
Jankauskas, S.S.; Gambardella, J.; Sardu, C.; Lombardi, A.; Santulli, G. Functional Role of miR-155 in the Pathogenesis of Diabetes Mellitus and Its Complications. Non-Coding RNA 2021, 7, 39. https://doi.org/10.3390/ncrna7030039
AMA Style
Jankauskas SS, Gambardella J, Sardu C, Lombardi A, Santulli G. Functional Role of miR-155 in the Pathogenesis of Diabetes Mellitus and Its Complications. Non-Coding RNA. 2021; 7(3):39. https://doi.org/10.3390/ncrna7030039
Chicago/Turabian StyleJankauskas, Stanislovas S., Jessica Gambardella, Celestino Sardu, Angela Lombardi, and Gaetano Santulli. 2021. "Functional Role of miR-155 in the Pathogenesis of Diabetes Mellitus and Its Complications" Non-Coding RNA 7, no. 3: 39. https://doi.org/10.3390/ncrna7030039
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