Herpes Simplex Virus 1 Deregulation of Host MicroRNAs
AbstractViruses utilize microRNAs (miRNAs) in a vast variety of possible interactions and mechanisms, apparently far beyond the classical understanding of gene repression in humans. Likewise, herpes simplex virus 1 (HSV-1) expresses numerous miRNAs and deregulates the expression of host miRNAs. Several HSV-1 miRNAs are abundantly expressed in latency, some of which are encoded antisense to transcripts of important productive infection genes, indicating their roles in repressing the productive cycle and/or in maintenance/reactivation from latency. In addition, HSV-1 also exploits host miRNAs to advance its replication or repress its genes to facilitate latency. Here, we discuss what is known about the functional interplay between HSV-1 and the host miRNA machinery, potential targets, and the molecular mechanisms leading to an efficient virus replication and spread. View Full-Text
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Cokarić Brdovčak, M.; Zubković, A.; Jurak, I. Herpes Simplex Virus 1 Deregulation of Host MicroRNAs. Non-Coding RNA 2018, 4, 36.
Cokarić Brdovčak M, Zubković A, Jurak I. Herpes Simplex Virus 1 Deregulation of Host MicroRNAs. Non-Coding RNA. 2018; 4(4):36.Chicago/Turabian Style
Cokarić Brdovčak, Maja; Zubković, Andreja; Jurak, Igor. 2018. "Herpes Simplex Virus 1 Deregulation of Host MicroRNAs." Non-Coding RNA 4, no. 4: 36.
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