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Non-Coding RNA 2018, 4(4), 36; https://doi.org/10.3390/ncrna4040036

Herpes Simplex Virus 1 Deregulation of Host MicroRNAs

Laboratory for Molecular Virology, Department of Biotechnology, University of Rijeka, R. Matejčić 2, HR-51000 Rijeka, Croatia
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Received: 24 October 2018 / Revised: 15 November 2018 / Accepted: 19 November 2018 / Published: 23 November 2018
(This article belongs to the Special Issue Non-Coding RNAs in Viral Infections)
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Abstract

Viruses utilize microRNAs (miRNAs) in a vast variety of possible interactions and mechanisms, apparently far beyond the classical understanding of gene repression in humans. Likewise, herpes simplex virus 1 (HSV-1) expresses numerous miRNAs and deregulates the expression of host miRNAs. Several HSV-1 miRNAs are abundantly expressed in latency, some of which are encoded antisense to transcripts of important productive infection genes, indicating their roles in repressing the productive cycle and/or in maintenance/reactivation from latency. In addition, HSV-1 also exploits host miRNAs to advance its replication or repress its genes to facilitate latency. Here, we discuss what is known about the functional interplay between HSV-1 and the host miRNA machinery, potential targets, and the molecular mechanisms leading to an efficient virus replication and spread. View Full-Text
Keywords: miRNAs; host–pathogen interaction; HSV-1; latency; productive replication; antiviral innate immune response; apoptosis miRNAs; host–pathogen interaction; HSV-1; latency; productive replication; antiviral innate immune response; apoptosis
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Cokarić Brdovčak, M.; Zubković, A.; Jurak, I. Herpes Simplex Virus 1 Deregulation of Host MicroRNAs. Non-Coding RNA 2018, 4, 36.

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