Next Article in Journal
Serum Levels of miR-148a and miR-21-5p Are Increased in Type 1 Diabetic Patients and Correlated with Markers of Bone Strength and Metabolism
Next Article in Special Issue
Gammaherpesvirus Readthrough Transcription Generates a Long Non-Coding RNA That Is Regulated by Antisense miRNAs and Correlates with Enhanced Lytic Replication In Vivo
Previous Article in Journal
Influence of Disease Duration on Circulating Levels of miRNAs in Children and Adolescents with New Onset Type 1 Diabetes
Previous Article in Special Issue
Contemporary Ribonomics Methods for Viral microRNA Target Analysis
Open AccessFeature PaperReview

Herpes Simplex Virus 1 Deregulation of Host MicroRNAs

Laboratory for Molecular Virology, Department of Biotechnology, University of Rijeka, R. Matejčić 2, HR-51000 Rijeka, Croatia
Author to whom correspondence should be addressed.
Non-Coding RNA 2018, 4(4), 36;
Received: 24 October 2018 / Revised: 15 November 2018 / Accepted: 19 November 2018 / Published: 23 November 2018
(This article belongs to the Special Issue Non-Coding RNAs in Viral Infections)
Viruses utilize microRNAs (miRNAs) in a vast variety of possible interactions and mechanisms, apparently far beyond the classical understanding of gene repression in humans. Likewise, herpes simplex virus 1 (HSV-1) expresses numerous miRNAs and deregulates the expression of host miRNAs. Several HSV-1 miRNAs are abundantly expressed in latency, some of which are encoded antisense to transcripts of important productive infection genes, indicating their roles in repressing the productive cycle and/or in maintenance/reactivation from latency. In addition, HSV-1 also exploits host miRNAs to advance its replication or repress its genes to facilitate latency. Here, we discuss what is known about the functional interplay between HSV-1 and the host miRNA machinery, potential targets, and the molecular mechanisms leading to an efficient virus replication and spread. View Full-Text
Keywords: miRNAs; host–pathogen interaction; HSV-1; latency; productive replication; antiviral innate immune response; apoptosis miRNAs; host–pathogen interaction; HSV-1; latency; productive replication; antiviral innate immune response; apoptosis
Show Figures

Figure 1

MDPI and ACS Style

Cokarić Brdovčak, M.; Zubković, A.; Jurak, I. Herpes Simplex Virus 1 Deregulation of Host MicroRNAs. Non-Coding RNA 2018, 4, 36.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop