Biogenesis, Stabilization, and Transport of microRNAs in Kidney Health and Disease
Abstract
:1. Introduction
The Kidneys
2. microRNAs
2.1. Discovery and Evolutionary Conservation of microRNAs
2.2. Biogenesis of miRNAs
2.3. microRNAs in Kidney Health and Disease
3. Intra-Nephron microRNA Transport
3.1. Extracellular Vesicle Nomenclature
3.2. Cellular Release of microRNAs
3.3. Extracellular microRNA Stability
3.4. Downstream Uptake of microRNAs
4. Conclusions
5. Patents
Author Contributions
Funding
Conflicts of Interest
References
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microRNA | Up/Down-Regulation in Disease/Model | Identified Target | Disease/Model | References |
---|---|---|---|---|
MiR-192 | Up | SIP-1 | Mouse Model, MCs (human, rat, mouse) | [33] |
Down | Zeb2 | DN patient samples, Proximal Tubule cells | [34,35] | |
MiR-29c | Up | Sprouty homolog-1/HIF1α | Mouse Model, MCs (mouse) | [36,37] |
MiR-21 | Up | Smad7 | Mouse Model, MCs (rat) | [38] |
Up | PPARa | Human Kidney Biopsy | [39] | |
Up | MMP-9, TIMP1 | Mouse Model, MCs (rat) | [40] | |
Down | PTEN | Mouse Model, Primary MCs (mouse) | [41] | |
MiR-215 | Up | CTNNBIP1 | Mouse Model, Primary MCs (mouse) | [37] |
Down | Zeb2 | Mouse Model, Primary MCs and PTCs (rat) | [35] | |
MiR-200b/c | Up | Zeb1/2 | Mouse Model, MCs (mouse), Endothelial cells | [42,43] |
MiR-29b | Down | TGFBR | Mouse Model | [44] |
MiR-216a | Up | PTEN Ybx1 | Mouse Model, Primary MCs (mouse) | [45] |
MiR-25 | Down | NOX4 | Human Biopsy, MCs | [46] |
MiR-29a | Down | COL4α1/2 | Proximal Tubule cells | [47] |
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Thomas, M.J.; Fraser, D.J.; Bowen, T. Biogenesis, Stabilization, and Transport of microRNAs in Kidney Health and Disease. Non-Coding RNA 2018, 4, 30. https://doi.org/10.3390/ncrna4040030
Thomas MJ, Fraser DJ, Bowen T. Biogenesis, Stabilization, and Transport of microRNAs in Kidney Health and Disease. Non-Coding RNA. 2018; 4(4):30. https://doi.org/10.3390/ncrna4040030
Chicago/Turabian StyleThomas, Melissa J., Donald J. Fraser, and Timothy Bowen. 2018. "Biogenesis, Stabilization, and Transport of microRNAs in Kidney Health and Disease" Non-Coding RNA 4, no. 4: 30. https://doi.org/10.3390/ncrna4040030