Next Article in Journal
Contemporary Ribonomics Methods for Viral microRNA Target Analysis
Previous Article in Journal
HCMV miRNA Targets Reveal Important Cellular Pathways for Viral Replication, Latency, and Reactivation
Previous Article in Special Issue
LncRNAs in TGF-β-Driven Tissue Fibrosis
Article Menu

Export Article

Open AccessFeature PaperReview
Non-Coding RNA 2018, 4(4), 30;

Biogenesis, Stabilization, and Transport of microRNAs in Kidney Health and Disease

Wales Kidney Research Unit, Division of Infection and Immunity, School of Medicine, College of Biomedical and Life Sciences, Cardiff University, Cardiff CF14 4XN, UK
Author to whom correspondence should be addressed.
Received: 28 September 2018 / Revised: 23 October 2018 / Accepted: 25 October 2018 / Published: 3 November 2018
(This article belongs to the Special Issue Non-Coding RNA, Fibrogenesis, and Fibrotic Disease)
Full-Text   |   PDF [2043 KB, uploaded 3 November 2018]   |  


The kidneys play key roles in the maintenance of homeostasis, including fluid balance, blood filtration, erythropoiesis and hormone production. Disease-driven perturbation of renal function therefore has profound pathological effects, and chronic kidney disease is a leading cause of morbidity and mortality worldwide. Successive annual increases in global chronic kidney disease patient numbers in part reflect upward trends for predisposing factors, including diabetes, obesity, hypertension, cardiovascular disease and population age. Each kidney typically possesses more than one million functional units called nephrons, and each nephron is divided into several discrete domains with distinct cellular and functional characteristics. A number of recent analyses have suggested that signaling between these nephron regions may be mediated by microRNAs. For this to be the case, several conditions must be fulfilled: (i) microRNAs must be released by upstream cells into the ultrafiltrate; (ii) these microRNAs must be packaged protectively to reach downstream cells intact; (iii) these packaged microRNAs must be taken up by downstream recipient cells without functional inhibition. This review will examine the evidence for each of these hypotheses and discuss the possibility that this signaling process might mediate pathological effects. View Full-Text
Keywords: microRNA; extracellular vesicle; chronic kidney disease microRNA; extracellular vesicle; chronic kidney disease

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Thomas, M.J.; Fraser, D.J.; Bowen, T. Biogenesis, Stabilization, and Transport of microRNAs in Kidney Health and Disease. Non-Coding RNA 2018, 4, 30.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Non-Coding RNA EISSN 2311-553X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top