Next Article in Journal
Copaifera langsdorffii Novel Putative Long Non-Coding RNAs: Interspecies Conservation Analysis in Adaptive Response to Different Biomes
Next Article in Special Issue
Biogenesis, Stabilization, and Transport of microRNAs in Kidney Health and Disease
Previous Article in Journal
MicroRNA-Attenuated Virus Vaccines
Previous Article in Special Issue
The Role of Long Non-Coding RNAs (lncRNAs) in the Development and Progression of Fibrosis Associated with Nonalcoholic Fatty Liver Disease (NAFLD)
Article Menu

Export Article

Open AccessReview
Non-Coding RNA 2018, 4(4), 26; https://doi.org/10.3390/ncrna4040026

LncRNAs in TGF-β-Driven Tissue Fibrosis

1
Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Lui Che Woo Institute of Innovative Medicine, Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong 999077, China
2
Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Hong Kong 999077, China
3
Department of Nephrology, Tongji University School of Medicine, Shanghai 200065, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 15 August 2018 / Revised: 22 September 2018 / Accepted: 28 September 2018 / Published: 4 October 2018
(This article belongs to the Special Issue Non-Coding RNA, Fibrogenesis, and Fibrotic Disease)
Full-Text   |   PDF [733 KB, uploaded 4 October 2018]   |  

Abstract

Transforming growth factor-β (TGF-β) is a crucial mediator in tissue fibrosis that promotes accumulation of extracellular matrix (ECM), myofibroblasts to epithelial–mesenchymal transition (EMT), endothelial-mesenchymal transition (EndoMT), and apoptosis via canonical and noncanonical signaling pathways. In the past decades, a number of microRNAs have been reported to participate in TGF-β-mediated tissue scarring; however, the roles of long noncoding RNAs (lncRNAs) in fibrogenesis remain largely unknown. Recently, emerging evidence has shown that lncRNAs are involved in the development of different diseases, including cancer, autoimmune diseases, cardiovascular diseases, and fibrotic diseases. In this review, we summarize the current updates of lncRNAs in TGF-β1-driven tissue fibrosis and discuss their therapeutic potential for the treatment of chronic fibrotic diseases. View Full-Text
Keywords: long noncoding RNA; fibrosis; transforming growth factor-β long noncoding RNA; fibrosis; transforming growth factor-β
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Tang, P.M.-K.; Zhang, Y.-Y.; Lan, H.-Y. LncRNAs in TGF-β-Driven Tissue Fibrosis. Non-Coding RNA 2018, 4, 26.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Non-Coding RNA EISSN 2311-553X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top