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The Role of Long Non-Coding RNAs (lncRNAs) in the Development and Progression of Fibrosis Associated with Nonalcoholic Fatty Liver Disease (NAFLD)
Open AccessReview

LncRNAs in TGF-β-Driven Tissue Fibrosis

by Patrick Ming-Kuen Tang 1,2,†, Ying-Ying Zhang 2,3,† and Hui-Yao Lan 2,*
1
Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Lui Che Woo Institute of Innovative Medicine, Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong 999077, China
2
Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Hong Kong 999077, China
3
Department of Nephrology, Tongji University School of Medicine, Shanghai 200065, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Non-Coding RNA 2018, 4(4), 26; https://doi.org/10.3390/ncrna4040026
Received: 15 August 2018 / Revised: 22 September 2018 / Accepted: 28 September 2018 / Published: 4 October 2018
(This article belongs to the Special Issue Non-Coding RNA, Fibrogenesis, and Fibrotic Disease)
Transforming growth factor-β (TGF-β) is a crucial mediator in tissue fibrosis that promotes accumulation of extracellular matrix (ECM), myofibroblasts to epithelial–mesenchymal transition (EMT), endothelial-mesenchymal transition (EndoMT), and apoptosis via canonical and noncanonical signaling pathways. In the past decades, a number of microRNAs have been reported to participate in TGF-β-mediated tissue scarring; however, the roles of long noncoding RNAs (lncRNAs) in fibrogenesis remain largely unknown. Recently, emerging evidence has shown that lncRNAs are involved in the development of different diseases, including cancer, autoimmune diseases, cardiovascular diseases, and fibrotic diseases. In this review, we summarize the current updates of lncRNAs in TGF-β1-driven tissue fibrosis and discuss their therapeutic potential for the treatment of chronic fibrotic diseases. View Full-Text
Keywords: long noncoding RNA; fibrosis; transforming growth factor-β long noncoding RNA; fibrosis; transforming growth factor-β
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Tang, P.M.-K.; Zhang, Y.-Y.; Lan, H.-Y. LncRNAs in TGF-β-Driven Tissue Fibrosis. Non-Coding RNA 2018, 4, 26.

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