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RNA Biomarkers: Frontier of Precision Medicine for Cancer

MOE Key Laboratory of Bioinformatics, Tsinghua‐Peking Joint Center for Life Sciences, Center for Plant Biology and Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China
Author to whom correspondence should be addressed.
Non-Coding RNA 2017, 3(1), 9;
Received: 30 December 2016 / Accepted: 13 February 2017 / Published: 20 February 2017
(This article belongs to the Special Issue Bioinformatics Softwares and Databases for Non-Coding RNA Research)
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As an essential part of central dogma, RNA delivers genetic and regulatory information and reflects cellular states. Based on high‐throughput sequencing technologies, cumulating data show that various RNA molecules are able to serve as biomarkers for the diagnosis and prognosis of various diseases, for instance, cancer. In particular, detectable in various bio‐fluids, such as serum, saliva and urine, extracellular RNAs (exRNAs) are emerging as non‐invasive biomarkers for earlier cancer diagnosis, tumor progression monitor, and prediction of therapy response. In this review, we summarize the latest studies on various types of RNA biomarkers, especially extracellular RNAs, in cancer diagnosis and prognosis, and illustrate several well‐known RNA biomarkers of clinical utility. In addition, we describe and discuss general procedures and issues in investigating exRNA biomarkers, and perspectives on utility of exRNAs in precision medicine. View Full-Text
Keywords: biomarker; exRNA; precision medicine; cancer biomarker; exRNA; precision medicine; cancer

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Xi, X.; Li, T.; Huang, Y.; Sun, J.; Zhu, Y.; Yang, Y.; Lu, Z.J. RNA Biomarkers: Frontier of Precision Medicine for Cancer. Non-Coding RNA 2017, 3, 9.

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