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Volume 9
Issue 4
10.3390/gels9040274
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Review

The Use of Hydrogels for the Treatment of Bone Osteosarcoma via Localized Drug-Delivery and Tissue Regeneration: A Narrative Review

by
Shebin Tharakan
1,
Iman Raja
1,
Annette Pietraru
2,
Elina Sarecha
2,
Andrei Gresita
1,
Eugen Petcu
1,
Azhar Ilyas
3 and
Michael Hadjiargyrou
2,*
1
College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, NY 11568, USA
2
Department of Biological and Chemical Sciences, New York Institute of Technology, Old Westbury, NY 11568, USA
3
Department of Electrical and Computing Engineering, New York Institute of Technology, Old Westbury, NY 11568, USA
*
Author to whom correspondence should be addressed.
Gels 2023, 9(4), 274; https://doi.org/10.3390/gels9040274
Submission received: 9 March 2023 / Revised: 22 March 2023 / Accepted: 23 March 2023 / Published: 25 March 2023
(This article belongs to the Special Issue Gel-Based Drug Delivery Systems for Cancer Treatment)
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Abstract

Osteosarcoma is a malignant tumor of bone that leads to poor mortality and morbidity. Management of this cancer through conventional methods involves invasive treatment options that place patients at an increased risk of adverse events. The use of hydrogels to target osteosarcoma has shown promising results both in vitro and in vivo to eradicate tumor cells while promoting bone regeneration. The loading of hydrogels with chemotherapeutic drugs provides a route for site-specific targeted therapy for osteosarcoma. Current studies demonstrate tumor regression in vivo and lysis of tumor cells in vitro when exposed to doped hydrogel scaffolds. Additionally, novel stimuli-responsive hydrogels are able to react with the tissue microenvironment to facilitate the controlled release of anti-tumor drugs and with biomechanical properties that can be modulated. This narrative review of the current literature discusses both in vitro and in vivo studies of different hydrogels, including stimuli-responsive, designed to treat bone osteosarcoma. Future applications to address patient treatment for this bone cancer are also discussed.
Keywords: osteosarcoma; hydrogels; bone; scaffold; tissue engineering; drug-delivery osteosarcoma; hydrogels; bone; scaffold; tissue engineering; drug-delivery

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MDPI and ACS Style

Tharakan, S.; Raja, I.; Pietraru, A.; Sarecha, E.; Gresita, A.; Petcu, E.; Ilyas, A.; Hadjiargyrou, M. The Use of Hydrogels for the Treatment of Bone Osteosarcoma via Localized Drug-Delivery and Tissue Regeneration: A Narrative Review. Gels 2023, 9, 274. https://doi.org/10.3390/gels9040274

AMA Style

Tharakan S, Raja I, Pietraru A, Sarecha E, Gresita A, Petcu E, Ilyas A, Hadjiargyrou M. The Use of Hydrogels for the Treatment of Bone Osteosarcoma via Localized Drug-Delivery and Tissue Regeneration: A Narrative Review. Gels. 2023; 9(4):274. https://doi.org/10.3390/gels9040274

Chicago/Turabian Style

Tharakan, Shebin, Iman Raja, Annette Pietraru, Elina Sarecha, Andrei Gresita, Eugen Petcu, Azhar Ilyas, and Michael Hadjiargyrou. 2023. "The Use of Hydrogels for the Treatment of Bone Osteosarcoma via Localized Drug-Delivery and Tissue Regeneration: A Narrative Review" Gels 9, no. 4: 274. https://doi.org/10.3390/gels9040274

APA Style

Tharakan, S., Raja, I., Pietraru, A., Sarecha, E., Gresita, A., Petcu, E., Ilyas, A., & Hadjiargyrou, M. (2023). The Use of Hydrogels for the Treatment of Bone Osteosarcoma via Localized Drug-Delivery and Tissue Regeneration: A Narrative Review. Gels, 9(4), 274. https://doi.org/10.3390/gels9040274

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