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Review

Injectable DNA Hydrogel-Based Local Drug Delivery and Immunotherapy

by 1,†, 1,†, 1, 1, 1, 2,*, 3 and 1,*
1
School of Life Sciences, Shanghai University, Shanghai 200444, China
2
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 201240, China
3
Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China
*
Authors to whom correspondence should be addressed.
These authors contribute equally to this work.
Academic Editor: Pietro Matricardi
Gels 2022, 8(7), 400; https://doi.org/10.3390/gels8070400
Received: 29 May 2022 / Revised: 13 June 2022 / Accepted: 16 June 2022 / Published: 24 June 2022
(This article belongs to the Special Issue Injectable Gels: Applications in Drug Delivery and Tissue Engineering)
Regulated drug delivery is an important direction in the field of medicine and healthcare research. In recent years, injectable hydrogels with good biocompatibility and biodegradability have attracted extensive attention due to their promising application in controlled drug release. Among them, DNA hydrogel has shown great potentials in local drug delivery and immunotherapy. DNA hydrogel is a three-dimensional network formed by cross-linking of hydrophilic DNA strands with extremely good biocompatibility. Benefiting from the special properties of DNA, including editable sequence and specificity of hybridization reactions, the mechanical properties and functions of DNA hydrogels can be precisely designed according to specific applications. In addition, other functional materials, including peptides, proteins and synthetic organic polymers can be easily integrated with DNA hydrogels, thereby enriching the functions of the hydrogels. In this review, we first summarize the types and synthesis methods of DNA hydrogels, and then review the recent research progress of injectable DNA hydrogels in local drug delivery, especially in immunotherapy. Finally, we discuss the challenges facing DNA hydrogels and future development directions. View Full-Text
Keywords: DNA; hydrogel; drug delivery; immunotherapy DNA; hydrogel; drug delivery; immunotherapy
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MDPI and ACS Style

Wang, Q.; Qu, Y.; Zhang, Z.; Huang, H.; Xu, Y.; Shen, F.; Wang, L.; Sun, L. Injectable DNA Hydrogel-Based Local Drug Delivery and Immunotherapy. Gels 2022, 8, 400. https://doi.org/10.3390/gels8070400

AMA Style

Wang Q, Qu Y, Zhang Z, Huang H, Xu Y, Shen F, Wang L, Sun L. Injectable DNA Hydrogel-Based Local Drug Delivery and Immunotherapy. Gels. 2022; 8(7):400. https://doi.org/10.3390/gels8070400

Chicago/Turabian Style

Wang, Qi, Yanfei Qu, Ziyi Zhang, Hao Huang, Yufei Xu, Fengyun Shen, Lihua Wang, and Lele Sun. 2022. "Injectable DNA Hydrogel-Based Local Drug Delivery and Immunotherapy" Gels 8, no. 7: 400. https://doi.org/10.3390/gels8070400

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