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Article

Drug Delivery from Hyaluronic Acid–BDDE Injectable Hydrogels for Antibacterial and Anti-Inflammatory Applications

1
i+Med S. Coop. Parque Tecnológico de Álava, Albert Einstein 15, Nave 15, 01510 Vitoria-Gasteiz, Spain
2
Grupo de Química Macromolecular (LABQUIMAC), Departamento de Química Física, Facultad de Ciencia y Tecnología, Universidad del País Vasco UPV/EHU, 48940 Leioa, Spain
3
BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940 Leioa, Spain
*
Author to whom correspondence should be addressed.
Academic Editors: Jie Gao, Yulin Li, Yuangang Liu and Tonghe Zhu
Gels 2022, 8(4), 223; https://doi.org/10.3390/gels8040223
Received: 6 March 2022 / Revised: 20 March 2022 / Accepted: 30 March 2022 / Published: 6 April 2022
(This article belongs to the Special Issue Injectable Gels: Applications in Drug Delivery and Tissue Engineering)
Hyaluronic acid (HA) injectable biomaterials are currently applied in numerous biomedical areas, beyond their use as dermal fillers. However, bacterial infections and painful inflammations are associated with healthcare complications that can appear after injection, restricting their applicability. Fortunately, HA injectable hydrogels can also serve as drug delivery platforms for the controlled release of bioactive agents with a critical role in the control of certain diseases. Accordingly, herein, HA hydrogels were crosslinked with 1 4-butanediol diglycidyl ether (BDDE) loaded with cefuroxime (CFX), tetracycline (TCN), and amoxicillin (AMX) antibiotics and acetylsalicylic acid (ASA) anti-inflammatory agent in order to promote antibacterial and anti-inflammatory responses. The hydrogels were thoroughly characterized and a clear correlation between the crosslinking grade and the hydrogels’ physicochemical properties was found after rheology, scanning electron microscopy (SEM), thermogravimetry (TGA), and differential scanning calorimetry (DSC) analyses. The biological safety of the hydrogels, expected due to the lack of BDDE residues observed in 1H-NMR spectroscopy, was also corroborated by an exhaustive biocompatibility test. As expected, the in vitro antibacterial and anti-inflammatory activity of the drug-loaded HA-BDDE hydrogels was confirmed against Staphylococcus aureus by significantly decreasing the pro-inflammatory cytokine levels. View Full-Text
Keywords: hyaluronic acid; injectable hydrogels; biocompatibility; drug delivery; antibacterial; anti-inflammatory hyaluronic acid; injectable hydrogels; biocompatibility; drug delivery; antibacterial; anti-inflammatory
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MDPI and ACS Style

Andrade del Olmo, J.; Pérez-Álvarez, L.; Sáez Martínez, V.; Benito Cid, S.; Pérez González, R.; Vilas-Vilela, J.L.; Alonso, J.M. Drug Delivery from Hyaluronic Acid–BDDE Injectable Hydrogels for Antibacterial and Anti-Inflammatory Applications. Gels 2022, 8, 223. https://doi.org/10.3390/gels8040223

AMA Style

Andrade del Olmo J, Pérez-Álvarez L, Sáez Martínez V, Benito Cid S, Pérez González R, Vilas-Vilela JL, Alonso JM. Drug Delivery from Hyaluronic Acid–BDDE Injectable Hydrogels for Antibacterial and Anti-Inflammatory Applications. Gels. 2022; 8(4):223. https://doi.org/10.3390/gels8040223

Chicago/Turabian Style

Andrade del Olmo, Jon, Leyre Pérez-Álvarez, Virginia Sáez Martínez, Sandra Benito Cid, Raúl Pérez González, José L. Vilas-Vilela, and José M. Alonso. 2022. "Drug Delivery from Hyaluronic Acid–BDDE Injectable Hydrogels for Antibacterial and Anti-Inflammatory Applications" Gels 8, no. 4: 223. https://doi.org/10.3390/gels8040223

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