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Encapsulation of Biological Agents in Hydrogels for Therapeutic Applications

1
Department of Chemical and Biological Engineering, Illinois Institute of Technology, 10 West 33rd Street, Chicago, IL 60616, USA
2
Departamento de Ingeniería Química, Universidad de Guadalajara, Blvd. Gral. Marcelino García Barragán # 1451, Guadalajara, Jalisco C.P. 44430, Mexico
*
Author to whom correspondence should be addressed.
Received: 10 May 2018 / Revised: 26 June 2018 / Accepted: 27 June 2018 / Published: 11 July 2018
(This article belongs to the Special Issue Hydrogels for Drug Delivery)
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Abstract

Hydrogels are materials specially suited for encapsulation of biological elements. Their large water content provides an environment compatible with most biological molecules. Their crosslinked nature also provides an ideal material for the protection of encapsulated biological elements against degradation and/or immune recognition. This makes them attractive not only for controlled drug delivery of proteins, but they can also be used to encapsulate cells that can have therapeutic applications. Thus, hydrogels can be used to create systems that will deliver required therapies in a controlled manner by either encapsulation of proteins or even cells that produce molecules that will be released from these systems. Here, an overview of hydrogel encapsulation strategies of biological elements ranging from molecules to cells is discussed, with special emphasis on therapeutic applications. View Full-Text
Keywords: hydrogel; controlled release; encapsulation; biocompatible; cell therapy hydrogel; controlled release; encapsulation; biocompatible; cell therapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Pérez-Luna, V.H.; González-Reynoso, O. Encapsulation of Biological Agents in Hydrogels for Therapeutic Applications. Gels 2018, 4, 61.

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