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Volume 11
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10.3390/gels11120951
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Collagen/Glutamate Composite Aerogels with Supramolecular Network Structures Fabricated by Regulating Self-Assembly Behavior for Drug Delivery System

by
Chengfei Yue
1,
Ying Yang
1,
Canhui Jiang
1,
Qingyu Wang
1,
Minjie Xu
1,
Liwen Xu
1,
Ming Yang
2,
Min Hu
1,* and
Ruquan Zhang
1,*
1
State Key Laboratory of New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan 430200, China
2
Hubei Integrative Technology and Innovation Center for Advanced Fiberous Materials, Wuhan 430200, China
*
Authors to whom correspondence should be addressed.
Gels 2025, 11(12), 951; https://doi.org/10.3390/gels11120951 (registering DOI)
Submission received: 22 October 2025 / Revised: 19 November 2025 / Accepted: 25 November 2025 / Published: 26 November 2025
(This article belongs to the Section Gel Applications)
Versions Notes

Abstract

Designing and developing multifunctional wound dressings with sustained drug-release capability is a promising strategy for minimizing the risks of wound infection and promoting wound healing. Collagen composite aerogels have been widely employed as a medical device building block, although they still fail to display competitive mechanical properties and sustained drug-release capability. Thus, we solve this challenge by pursuing a multi-scale design method, which utilizes glutamic acid (Glu) to regulate the collagen self-assembly behavior to obtain a network-structured collagen/glutamate composite aerogel with sustained drug release, biocompatibility, and hemostatic ability. Through structural and performance analysis, the Glu endows collagen composite aerogels with excellent structural stability and superior mechanical properties by regulating the intermolecular interaction between collagen molecules, which made the aerogels achieve a supramolecular network structure through the entanglement of high-density collagen fibrils and showed excellent sustained drug-release characteristics. Moreover, collagen/Glu composite aerogels also exhibited outstanding biocompatibility and hemostatic capability. This self-assembly strategy provides new insight aimed at collagen composite aerogels with supramolecular network structures and sustained drug-release capability, making them a promising candidate for wound dressings in future clinical applications.
Keywords: collagen; glutamate; self-assembly; aerogels; drug delivery; hemostatic capability collagen; glutamate; self-assembly; aerogels; drug delivery; hemostatic capability

Share and Cite

MDPI and ACS Style

Yue, C.; Yang, Y.; Jiang, C.; Wang, Q.; Xu, M.; Xu, L.; Yang, M.; Hu, M.; Zhang, R. Collagen/Glutamate Composite Aerogels with Supramolecular Network Structures Fabricated by Regulating Self-Assembly Behavior for Drug Delivery System. Gels 2025, 11, 951. https://doi.org/10.3390/gels11120951

AMA Style

Yue C, Yang Y, Jiang C, Wang Q, Xu M, Xu L, Yang M, Hu M, Zhang R. Collagen/Glutamate Composite Aerogels with Supramolecular Network Structures Fabricated by Regulating Self-Assembly Behavior for Drug Delivery System. Gels. 2025; 11(12):951. https://doi.org/10.3390/gels11120951

Chicago/Turabian Style

Yue, Chengfei, Ying Yang, Canhui Jiang, Qingyu Wang, Minjie Xu, Liwen Xu, Ming Yang, Min Hu, and Ruquan Zhang. 2025. "Collagen/Glutamate Composite Aerogels with Supramolecular Network Structures Fabricated by Regulating Self-Assembly Behavior for Drug Delivery System" Gels 11, no. 12: 951. https://doi.org/10.3390/gels11120951

APA Style

Yue, C., Yang, Y., Jiang, C., Wang, Q., Xu, M., Xu, L., Yang, M., Hu, M., & Zhang, R. (2025). Collagen/Glutamate Composite Aerogels with Supramolecular Network Structures Fabricated by Regulating Self-Assembly Behavior for Drug Delivery System. Gels, 11(12), 951. https://doi.org/10.3390/gels11120951

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