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Volume 11
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10.3390/gels11010066
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Review

Polydiacetylene (PDA) Embedded Polymer-Based Network Structure for Biosensor Applications

by
Huisoo Jang
1,2,
Junhyeon Jeon
2,3,
Mingyeong Shin
4,
Geonha Kang
3,
Hyunil Ryu
2,
Sun Min Kim
2,3,5,* and
Tae-Joon Jeon
2,5,6,*
1
Industrial Science and Technology Research Institute, Inha University, 100 Inha-ro, Michuhol-gu, Incheon 22212, Republic of Korea
2
Biohybrid Systems Research Center (BSRC), Inha University, 100 Inha-ro, Michuhol-gu, Incheon 22212, Republic of Korea
3
Department of Mechanical Engineering, Inha University, 100 Inha-ro, Michuhol-gu, Incheon 22212, Republic of Korea
4
Department of Food and Nutrition, Inha University, 100 Inha-ro, Michuhol-gu, Incheon 22212, Republic of Korea
5
Department of Biological Sciences and Bioengineering, Inha University, 100 Inha-ro, Michuhol-gu, Incheon 22212, Republic of Korea
6
Department of Biological Engineering, Inha University, 100 Inha-ro, Michuhol-gu, Incheon 22212, Republic of Korea
*
Authors to whom correspondence should be addressed.
Gels 2025, 11(1), 66; https://doi.org/10.3390/gels11010066
Submission received: 15 November 2024 / Revised: 11 January 2025 / Accepted: 13 January 2025 / Published: 15 January 2025
(This article belongs to the Special Issue Recent Progress of Hydrogel Sensors and Biosensors)
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Abstract

Biosensors, which combine physical transducers with biorecognition elements, have seen significant advancement due to the heightened interest in rapid diagnostic technologies across a number of fields, including medical diagnostics, environmental monitoring, and food safety. In particular, polydiacetylene (PDA) is gaining attention as an ideal material for label-free colorimetric biosensor development due to its unique color-changing properties in response to external stimuli. PDA forms through the self-assembly of diacetylene monomers, with color change occurring as its conjugated backbone twists in response to stimuli such as temperature, pH, and chemical interactions. This color change enables the detection of biomarkers, metal ions, and toxic compounds. Moreover, the combination of PDA with polymeric structures including hydrogels further enhances the sensitivity and structural stability of PDA-based biosensors, making them reliable and effective in complex biological and environmental conditions. This review comprehensively examines recent research trends and applications of PDA–polymeric structure hybrid biosensors, while discussing future directions and potential advancements in this field.
Keywords: colorimetric biosensors; polydiacetylene; hydrogel; polymeric structure; synthetic polymers; point-of-care detection colorimetric biosensors; polydiacetylene; hydrogel; polymeric structure; synthetic polymers; point-of-care detection

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MDPI and ACS Style

Jang, H.; Jeon, J.; Shin, M.; Kang, G.; Ryu, H.; Kim, S.M.; Jeon, T.-J. Polydiacetylene (PDA) Embedded Polymer-Based Network Structure for Biosensor Applications. Gels 2025, 11, 66. https://doi.org/10.3390/gels11010066

AMA Style

Jang H, Jeon J, Shin M, Kang G, Ryu H, Kim SM, Jeon T-J. Polydiacetylene (PDA) Embedded Polymer-Based Network Structure for Biosensor Applications. Gels. 2025; 11(1):66. https://doi.org/10.3390/gels11010066

Chicago/Turabian Style

Jang, Huisoo, Junhyeon Jeon, Mingyeong Shin, Geonha Kang, Hyunil Ryu, Sun Min Kim, and Tae-Joon Jeon. 2025. "Polydiacetylene (PDA) Embedded Polymer-Based Network Structure for Biosensor Applications" Gels 11, no. 1: 66. https://doi.org/10.3390/gels11010066

APA Style

Jang, H., Jeon, J., Shin, M., Kang, G., Ryu, H., Kim, S. M., & Jeon, T.-J. (2025). Polydiacetylene (PDA) Embedded Polymer-Based Network Structure for Biosensor Applications. Gels, 11(1), 66. https://doi.org/10.3390/gels11010066

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