Rheological and Injectability Evaluation of Sterilized Poloxamer-407-Based Hydrogels Containing Docetaxel-Loaded Lipid Nanoparticles
Abstract
:1. Introduction
2. Results and Discussion
2.1. Preparation of Nanocomposite Hydrogels
2.2. Characterization of Nanocomposite Hydrogels
2.2.1. Rheological Behavior
Sol–Gel Transition
Frequency Sweeps
2.2.2. Injectability
2.2.3. Chemical and Thermal Stability
Chemical Characterization
Thermal Properties
3. Conclusions
4. Materials and Methods
4.1. Materials
4.2. Preparation of Nanocomposite Hydrogels
4.3. Characterization of Nanocomposite Hydrogels
4.3.1. Rheology
4.3.2. Injectability Test
4.3.3. Fourier-Transform Infrared Spectroscopy
4.3.4. Differential Scanning Calorimetry
4.3.5. Statistical Analysis
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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HG | Tsol-gel (°C) | Gelation Time (s) | 25 °C | 25 °C | 37 °C | 37 °C |
---|---|---|---|---|---|---|
G′ (Pa) * | G″ (Pa) * | G′ (Pa) * | G″ (Pa) * | |||
Blank HG | 30.8 ± 0.6 | 0 | 0.11 | 0.30 | 11,216.7 | 1418.3 |
Blank sHG | 30.6 ± 1.5 | 0 | 0.08 | 0.30 | 10,737.3 | 1137.7 |
HG-NLC | 33.1 ± 0.6 | 0 | 4.63 | 7.33 | 6040.3 | 1106.0 |
sHG-NLC | 39.0 ± 0.4 | 70.7 ± 6.9 | 5.81 | 11.24 | 546.3 | 255.8 |
HG-NLC-DTX | 34.3 ± 0.5 | 50.8 ± 5.0 | 10.34 | 12.55 | 3036.7 | 824.8 |
sHG-NLC-DTX | 38.4 ± 1.3 | 40.1 ± 6.5 | 4.17 | 11.11 | 700.5 | 268.5 |
HG | Onset (°C) | Peak (°C) | Enthalpy (J/g) |
---|---|---|---|
Blank HG | 52.7 | 56.8 | 150.9 |
Blank sHG | 53.2 | 56.4 | 181.1 |
HG-NLC | 50.5 | 54.2 | 144.0 |
sHG-NLC | 49.9 | 53.4 | 134.1 |
HG-NLC-DTX | 51.7 | 54.7 | 124.6 |
sHG-NLC-DTX | 50.2 | 53.8 | 144.7 |
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Marques, A.C.; Costa, P.C.; Velho, S.; Amaral, M.H. Rheological and Injectability Evaluation of Sterilized Poloxamer-407-Based Hydrogels Containing Docetaxel-Loaded Lipid Nanoparticles. Gels 2024, 10, 307. https://doi.org/10.3390/gels10050307
Marques AC, Costa PC, Velho S, Amaral MH. Rheological and Injectability Evaluation of Sterilized Poloxamer-407-Based Hydrogels Containing Docetaxel-Loaded Lipid Nanoparticles. Gels. 2024; 10(5):307. https://doi.org/10.3390/gels10050307
Chicago/Turabian StyleMarques, Ana Camila, Paulo C. Costa, Sérgia Velho, and Maria Helena Amaral. 2024. "Rheological and Injectability Evaluation of Sterilized Poloxamer-407-Based Hydrogels Containing Docetaxel-Loaded Lipid Nanoparticles" Gels 10, no. 5: 307. https://doi.org/10.3390/gels10050307
APA StyleMarques, A. C., Costa, P. C., Velho, S., & Amaral, M. H. (2024). Rheological and Injectability Evaluation of Sterilized Poloxamer-407-Based Hydrogels Containing Docetaxel-Loaded Lipid Nanoparticles. Gels, 10(5), 307. https://doi.org/10.3390/gels10050307