Review Reports

Round 1

Reviewer 1 Report

Please, see the attached document.

Comments for author File: Comments.pdf

Author Response

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Author Response File: Author Response.doc

Reviewer 2 Report

The article by Sekar et al., is a study of the prevalence of histoplasmosis in advanced HIV patients. Since histoplasmosis is a neglected disease in Africa, that is probably underdiagnosed, this study seems me interesting. The articles is well written and results are clear. Just some comments:

In my opinion trying to confirm histoplasmosis in the positive patients would have been very interesting. Other techniques such as PCR could have been a good option. Didn't the authors consider this option?

Rule out the possibility of that H. capsulatum var duboisii strains do not work in the antigen test is also interesting. An “in vitro” assay could have been interesting.

 

Author Response

Please see the attachment.

Author Response File: Author Response.doc