Secondary Metabolites from Marine-Derived Fungus Penicillium rubens BTBU20213035

Xu, Xiuli; Dong, Yifei; Yang, Jinpeng; Wang, Long; Ma, Linlin; Song, Fuhang; Ma, Xiaoli

doi:10.3390/jof10060424

Open AccessArticle

Secondary Metabolites from Marine-Derived Fungus Penicillium rubens BTBU20213035

by

Xiuli Xu

¹,

Yifei Dong

²,

Jinpeng Yang

¹,

Long Wang

³

,

Linlin Ma

⁴,

Fuhang Song

^2,*

and

Xiaoli Ma

^5,*

¹

Key Laboratory of Marine Mineral Resources and Polar Geology, Ministry of Education, School of Ocean Sciences, China University of Geosciences, Beijing 100083, China

²

Key Laboratory of Geriatric Nutrition and Health, Ministry of Education of China, School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, China

³

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

⁴

Griffith Institute for Drug Discovery, School of Environment and Science, Griffith University, Brisbane 4111, Australia

⁵

School of Chemistry and Chemical Engineering, North Minzu University, Yinchuan 750021, China

^*

Authors to whom correspondence should be addressed.

J. Fungi 2024, 10(6), 424; https://doi.org/10.3390/jof10060424

Submission received: 21 May 2024 / Revised: 13 June 2024 / Accepted: 14 June 2024 / Published: 16 June 2024

(This article belongs to the Special Issue The Gift of Marine Fungi: Abundant Secondary Metabolites)

Download

Browse Figures

Versions Notes

Abstract

Two new polyketide derivatives, penirubenones A and B (1 and 2), and two naturally rare amino-bis-tetrahydrofuran derivatives, penirubenamides A and B (3 and 4), together with nine known compounds (5–13) were isolated from the marine-derived fungus Penicillium rubens BTBU20213035. The structures were identified by HRESIMS and 1D and 2D NMR analyses, and their absolute configurations were determined by a comparison of experimental and calculated electronic circular dichroism (ECD) spectroscopy and ¹³C NMR data. We found that 6 exhibited antibacterial activity against Staphylococcus aureus, with an MIC value of 3.125 μg/mL, and 1 and 2 showed synergistic antifungal activity against Candida albicans at 12.5 and 50 μg/mL with 0.0625 μg/mL rapamycin.

Keywords: marine-derived fungus; Penicillium rubens; polyketide; bis-tetrahydrofuran; antibacterial; synergistic antifungal

Share and Cite

MDPI and ACS Style

Xu, X.; Dong, Y.; Yang, J.; Wang, L.; Ma, L.; Song, F.; Ma, X. Secondary Metabolites from Marine-Derived Fungus Penicillium rubens BTBU20213035. J. Fungi 2024, 10, 424. https://doi.org/10.3390/jof10060424

AMA Style

Xu X, Dong Y, Yang J, Wang L, Ma L, Song F, Ma X. Secondary Metabolites from Marine-Derived Fungus Penicillium rubens BTBU20213035. Journal of Fungi. 2024; 10(6):424. https://doi.org/10.3390/jof10060424

Chicago/Turabian Style

Xu, Xiuli, Yifei Dong, Jinpeng Yang, Long Wang, Linlin Ma, Fuhang Song, and Xiaoli Ma. 2024. "Secondary Metabolites from Marine-Derived Fungus Penicillium rubens BTBU20213035" Journal of Fungi 10, no. 6: 424. https://doi.org/10.3390/jof10060424

APA Style

Xu, X., Dong, Y., Yang, J., Wang, L., Ma, L., Song, F., & Ma, X. (2024). Secondary Metabolites from Marine-Derived Fungus Penicillium rubens BTBU20213035. Journal of Fungi, 10(6), 424. https://doi.org/10.3390/jof10060424

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Secondary Metabolites from Marine-Derived Fungus Penicillium rubens BTBU20213035

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI