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Review

Importance of Clinical Isolates in Cryptococcus neoformans Research

by
Katrina M. Jackson
†,
Minna Ding
† and
Kirsten Nielsen
*
Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Fungi 2023, 9(3), 364; https://doi.org/10.3390/jof9030364
Submission received: 20 February 2023 / Revised: 9 March 2023 / Accepted: 13 March 2023 / Published: 16 March 2023
(This article belongs to the Special Issue Women in Mycology)
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Abstract

The human pathogenic fungus Cryptococcus neoformans is a global health concern. Previous research in the field has focused on studies using reference strains to identify virulence factors, generate mutant libraries, define genomic structures, and perform functional studies. In this review, we discuss the benefits and drawbacks of using reference strains to study C. neoformans, describe how the study of clinical isolates has expanded our understanding of pathogenesis, and highlight how studies using clinical isolates can further develop our understanding of the host–pathogen interaction during C. neoformans infection.
Keywords: Cryptococcus neoformans; clinical isolates; host–pathogen interaction; genotype Cryptococcus neoformans; clinical isolates; host–pathogen interaction; genotype

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MDPI and ACS Style

Jackson, K.M.; Ding, M.; Nielsen, K. Importance of Clinical Isolates in Cryptococcus neoformans Research. J. Fungi 2023, 9, 364. https://doi.org/10.3390/jof9030364

AMA Style

Jackson KM, Ding M, Nielsen K. Importance of Clinical Isolates in Cryptococcus neoformans Research. Journal of Fungi. 2023; 9(3):364. https://doi.org/10.3390/jof9030364

Chicago/Turabian Style

Jackson, Katrina M., Minna Ding, and Kirsten Nielsen. 2023. "Importance of Clinical Isolates in Cryptococcus neoformans Research" Journal of Fungi 9, no. 3: 364. https://doi.org/10.3390/jof9030364

APA Style

Jackson, K. M., Ding, M., & Nielsen, K. (2023). Importance of Clinical Isolates in Cryptococcus neoformans Research. Journal of Fungi, 9(3), 364. https://doi.org/10.3390/jof9030364

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