Next Article in Journal
Antimicrobial Volatiles of the Insect Pathogen Metarhizium brunneum
Next Article in Special Issue
Biochemical Approaches on Commercial Strains of Agaricus subrufescens Growing under Two Environmental Cultivation Conditions
Previous Article in Journal
Ultrahigh-Throughput Screening of High-β-Xylosidase-Producing Penicillium piceum and Investigation of the Novel β-Xylosidase Characteristics
Previous Article in Special Issue
Edible Mushrooms as Novel Myco-Therapeutics: Effects on Lipid Level, Obesity and BMI
 
 
Article

Efficacy of Cordyceps militaris Extracts against Some Skin Pathogenic Bacteria and Antioxidant Activity

1
Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
2
Graduate School, Chiang Mai University, Chiang Mai 50200, Thailand
3
Research Center in Bioresource for Agriculture, Industry, and Medicine, Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
*
Author to whom correspondence should be addressed.
Academic Editors: Jasmina Glamočlija and Dejan Stojković
J. Fungi 2022, 8(4), 327; https://doi.org/10.3390/jof8040327
Received: 6 March 2022 / Revised: 18 March 2022 / Accepted: 19 March 2022 / Published: 22 March 2022
(This article belongs to the Special Issue Mushrooms—Mycotherapy and Mycochemistry 2.0)
Cordyceps militaris has been used for treating various diseases, as well as maintaining good overall health. The antibacterial properties of the C. militaris fruiting body and substrate, cultured in Chiang Mai (sample A and B) and Chiang Rai (sample C), Thailand, were investigated in this study. The aqueous and ethanolic extracts of C. militaris exhibited antibacterial activities against Staphylococcus aureus, Pseudomonas aeruginosa, Cutibacterium acnes and methicillin-resistant S. aureus (MRSA) with the MIC/MBC ranging from 3.91 to 31.25 mg/mL. The ethanolic extracts of the fruiting body and substrate from sample B also inhibited all bacterial growth within 2–4 h of treatment. Furthermore, ethanolic extract from sample B showed the highest cordycepin content of 57.42 mg/g extract, whereas the highest adenosine content, 3.78 mg/g extract, was observed in the ethanolic extract from the fruiting body of sample A by HPLC. The ethanolic extracts from sample A also demonstrated the highest antioxidant activity and flavonoid content by 9.50 mg GAE/g extract and 10.59 mg QAE/g extract, respectively. However, the highest phenolic content of 49.04 mg GAE/g extract was found in the aqueous extract of sample A. In addition, the ethanolic extract of sample A at 2 and 4 mg/mL could significantly down-regulate the mecA gene expression in MRSA. Our findings reported the potential of C. militaris extract as a new substance for the treatment of skin pathogenic bacteria infections and an antioxidant agent. View Full-Text
Keywords: Cordyceps militaris; cordycepin; antibacterial activity; skin pathogenic bacteria; antioxidant activity Cordyceps militaris; cordycepin; antibacterial activity; skin pathogenic bacteria; antioxidant activity
Show Figures

Figure 1

MDPI and ACS Style

Eiamthaworn, K.; Kaewkod, T.; Bovonsombut, S.; Tragoolpua, Y. Efficacy of Cordyceps militaris Extracts against Some Skin Pathogenic Bacteria and Antioxidant Activity. J. Fungi 2022, 8, 327. https://doi.org/10.3390/jof8040327

AMA Style

Eiamthaworn K, Kaewkod T, Bovonsombut S, Tragoolpua Y. Efficacy of Cordyceps militaris Extracts against Some Skin Pathogenic Bacteria and Antioxidant Activity. Journal of Fungi. 2022; 8(4):327. https://doi.org/10.3390/jof8040327

Chicago/Turabian Style

Eiamthaworn, Kiratiya, Thida Kaewkod, Sakunnee Bovonsombut, and Yingmanee Tragoolpua. 2022. "Efficacy of Cordyceps militaris Extracts against Some Skin Pathogenic Bacteria and Antioxidant Activity" Journal of Fungi 8, no. 4: 327. https://doi.org/10.3390/jof8040327

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop