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Article

Pneumocystis spp. in Pigs: A Longitudinal Quantitative Study and Co-Infection Assessment in Austrian Farms

1
Department for Pathobiology, Institute of Pathology, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria
2
Department for Farm Animals and Veterinary Public Health, Clinic for Swine, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria
3
Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health (NIH), 10 Center Drive, Bethesda, MD 20892, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Enrique J. Calderón, Robert F. Miller and Yaxsier de Armas
J. Fungi 2022, 8(1), 43; https://doi.org/10.3390/jof8010043
Received: 24 November 2021 / Revised: 22 December 2021 / Accepted: 28 December 2021 / Published: 31 December 2021
(This article belongs to the Special Issue Advances in Pneumocystis Infection)
While Pneumocystis has been recognized as both a ubiquitous commensal fungus in immunocompetent mammalian hosts and a major opportunistic pathogen in humans responsible for severe pneumonias in immunocompromised patients, in pigs its epidemiology and association with pulmonary diseases have been rarely reported. Nevertheless, the fungus can be quite abundant in porcine populations with up to 51% of prevalence reported so far. The current study was undertaken to longitudinally quantify Pneumocystis carinii f. sp. suis and other pulmonary pathogens in a cohort of 50 pigs from five Austrian farms (i.e., 10 pigs per farm) with a history of respiratory disease at five time points between the first week and the fourth month of life. The fungus was present as early as the suckling period (16% and 26% of the animals in the first and the third week, respectively), yet not in a high amount. Over time, both the organism load (highest 4.4 × 105 copies/mL) and prevalence (up to 88% of positive animals in the third month) increased in each farm. The relative prevalence of various coinfection patterns was significantly different over time. The current study unravelled a complex co-infection history involving Pneumocystis and other pulmonary pathogens in pigs, suggesting a relevant role of the fungus in the respiratory disease scenario of this host. View Full-Text
Keywords: Pneumocystis spp.; pig; farms; respiratory diseases; PRDC Pneumocystis spp.; pig; farms; respiratory diseases; PRDC
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MDPI and ACS Style

Blasi, B.; Sipos, W.; Knecht, C.; Dürlinger, S.; Ma, L.; Cissé, O.H.; Nedorost, N.; Matt, J.; Weissenböck, H.; Weissenbacher-Lang, C. Pneumocystis spp. in Pigs: A Longitudinal Quantitative Study and Co-Infection Assessment in Austrian Farms. J. Fungi 2022, 8, 43. https://doi.org/10.3390/jof8010043

AMA Style

Blasi B, Sipos W, Knecht C, Dürlinger S, Ma L, Cissé OH, Nedorost N, Matt J, Weissenböck H, Weissenbacher-Lang C. Pneumocystis spp. in Pigs: A Longitudinal Quantitative Study and Co-Infection Assessment in Austrian Farms. Journal of Fungi. 2022; 8(1):43. https://doi.org/10.3390/jof8010043

Chicago/Turabian Style

Blasi, Barbara, Wolfgang Sipos, Christian Knecht, Sophie Dürlinger, Liang Ma, Ousmane H. Cissé, Nora Nedorost, Julia Matt, Herbert Weissenböck, and Christiane Weissenbacher-Lang. 2022. "Pneumocystis spp. in Pigs: A Longitudinal Quantitative Study and Co-Infection Assessment in Austrian Farms" Journal of Fungi 8, no. 1: 43. https://doi.org/10.3390/jof8010043

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