Chronic Pulmonary Aspergillosis Situation among Post Tuberculosis Patients in Vietnam: An Observational Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Clinical Samples and Radiological Findings
2.3. Serology Test
2.4. Treatment
2.5. Statistical Analysis
2.6. Ethical Issues
3. Results
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
References
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Features | No. | Statistics |
---|---|---|
Baseline demographics | ||
CPA confirmed cases | 40 | |
Age mean (SD)/Median (IQR) | 59 | 2.3 (54.4–63.6) |
Males | 28 | 73.7% |
Females | 10 | 26.3% |
BMI | 19.0 | 0.49 (18.0–20.0) |
Comorbidities | ||
Diabetes | 5 | 12.5% |
COPD | 8 | 20% |
Bronchiectasis | 3 | 7.5% |
Interval after TB to CPA presentation | ||
<5 years | 9 | 27.3% |
5–10 years | 10 | 30.3% |
>10 years | 14 | 42.4% |
Clinical symptoms | ||
Cough | 37 | 97.4% |
Productive cough | 31 | 81.6% |
Hemoptysis | 18 | 47.4% |
Dyspnea | 21 | 55.3% |
Fever | 8 | 21.1% |
Weight loss | 14 | 36.8% |
Chest X-ray radiological findings | ||
Cavitary lesion | 8 | 21.1% |
Aspergilloma | 5 | 13.2% |
Pleural thickening | 30 | 79.0% |
Hemithorax | 5 | 21.1% |
Chest CT findings | ||
Bilateral | 19 | 50.0% |
Left | 7 | 18.4% |
Right | 12 | 31.6% |
Multiple cavities with thickened pleura | 20 | 52.6% |
Fungal ball(s) (aspergilloma) | 11 | 28.9% |
Single cavity with thickened pleura | 6 | 15.8% |
Pleural thickening | 17 | 44.7% |
Bronchiectasis | 10 | 26.3% |
Non-specific infiltrates | 11 | 28.9% |
Blood Test | Mean/Median | SD/IQR | Normal Range |
WBC | 10.6 | 4.9 | 4.5–11. 0 |
CRP | 60.9 | 71.7 | 0–5.0 |
Aspergillus IgG | 2.82 | 1.9 | <0.9 |
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Nguyen, N.T.B.; Le Ngoc, H.; Nguyen, N.V.; Dinh, L.V.; Nguyen, H.V.; Nguyen, H.T.; Denning, D.W. Chronic Pulmonary Aspergillosis Situation among Post Tuberculosis Patients in Vietnam: An Observational Study. J. Fungi 2021, 7, 532. https://doi.org/10.3390/jof7070532
Nguyen NTB, Le Ngoc H, Nguyen NV, Dinh LV, Nguyen HV, Nguyen HT, Denning DW. Chronic Pulmonary Aspergillosis Situation among Post Tuberculosis Patients in Vietnam: An Observational Study. Journal of Fungi. 2021; 7(7):532. https://doi.org/10.3390/jof7070532
Chicago/Turabian StyleNguyen, Ngoc Thi Bich, Huy Le Ngoc, Nhung Viet Nguyen, Luong Van Dinh, Hung Van Nguyen, Huyen Thi Nguyen, and David W. Denning. 2021. "Chronic Pulmonary Aspergillosis Situation among Post Tuberculosis Patients in Vietnam: An Observational Study" Journal of Fungi 7, no. 7: 532. https://doi.org/10.3390/jof7070532