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Article

CD137 Signaling Is Critical in Fungal Clearance during Systemic Candida albicans Infection

School of Biological Science, University of Ulsan, Ulsan 44610, Korea
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Author to whom correspondence should be addressed.
Present address: Center for Immunology and Infectious Diseases, University of California at Davis, Davis, CA 95616-5270, USA
Academic Editor: Sofia Costa-de-Oliveira
J. Fungi 2021, 7(5), 382; https://doi.org/10.3390/jof7050382
Received: 26 March 2021 / Revised: 11 May 2021 / Accepted: 12 May 2021 / Published: 14 May 2021
(This article belongs to the Special Issue Invasive Candidiasis)
Invasive fungal infections by Candida albicans frequently cause mortality in immunocompromised patients. Neutrophils are particularly important for fungal clearance during systemic C. albican infection, yet little has been known regarding which surface receptor controls neutrophils’ antifungal activities. CD137, which is encoded by Tnfrsf9, belongs to the tumor necrosis receptor superfamily and has been shown to regulate neutrophils in Gram-positive bacterial infection. Here, we used genetic and immunological tools to probe the involvement of neutrophil CD137 signaling in innate defense mechanisms against systemic C. albicans infection. We first found that Tnfrsf9−/− mice were susceptible to C. albicans infection, whereas injection of anti-CD137 agonistic antibody protected the host from infection, suggesting that CD137 signaling is indispensable for innate immunity against C. albicans infection. Priming of isolated neutrophils with anti-CD137 antibody promoted their phagocytic and fungicidal activities through phospholipase C. In addition, injection of anti-CD137 antibody significantly augmented restriction of fungal growth in Tnfrsf9−/− mice that received wild-type (WT) neutrophils. In conclusion, our results demonstrate that CD137 signaling contributes to defense mechanisms against systemic C. albicans infection by promoting rapid fungal clearance. View Full-Text
Keywords: Candida albicans; CD137; neutrophil; fungal clearance Candida albicans; CD137; neutrophil; fungal clearance
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MDPI and ACS Style

Tran, V.G.; Nguyen, N.N.Z.; Kwon, B. CD137 Signaling Is Critical in Fungal Clearance during Systemic Candida albicans Infection. J. Fungi 2021, 7, 382. https://doi.org/10.3390/jof7050382

AMA Style

Tran VG, Nguyen NNZ, Kwon B. CD137 Signaling Is Critical in Fungal Clearance during Systemic Candida albicans Infection. Journal of Fungi. 2021; 7(5):382. https://doi.org/10.3390/jof7050382

Chicago/Turabian Style

Tran, Vuvi G., Na N. Z. Nguyen, and Byungsuk Kwon. 2021. "CD137 Signaling Is Critical in Fungal Clearance during Systemic Candida albicans Infection" Journal of Fungi 7, no. 5: 382. https://doi.org/10.3390/jof7050382

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