Next Article in Journal
Variable Correlation between Bronchoalveolar Lavage Fluid Fungal Load and Serum-(1,3)-β-d-Glucan in Patients with Pneumocystosis—A Multicenter ECMM Excellence Center Study
Next Article in Special Issue
Summary of Guidelines for Managing Histoplasmosis among People Living with HIV
Previous Article in Journal
Agrobacterium tumefaciens-Mediated Transformation of Fonsecaea monophora and Fonsecaea erecta for Host-Environment Interaction Studies
Previous Article in Special Issue
Detection of Histoplasma DNA from Tissue Blocks by a Specific and a Broad-Range Real-Time PCR: Tools to Elucidate the Epidemiology of Histoplasmosis
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JoF
Volume 6
Issue 4
10.3390/jof6040326
jof-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Risk Factors for Mortality among HIV-Infected Patients with Disseminated Histoplasmosis

by
Mathieu Nacher
1,2,*,
Kinan Drak Alsibai
3,
Audrey Valdes
4,
Romain Blaizot
2,5,
Philippe Abboud
6,
Magalie Demar
7,8,
Félix Djossou
6,
Loïc Epelboin
6,
Caroline Misslin
9,
Balthazar Ntab
10,
Antoine Adenis
1,2 and
Pierre Couppié
2,5
1
CIC INSERM 1424, Centre Hospitalier AndreeRosemon Cayenne, 97300 Cayenne, France
2
DFR Santé, Université de Guyane, 97300 Cayenne, France
3
Department of Pathology, Centre Hospitalier AndreeRosemon Cayenne, 97300 Cayenne, France
4
Equipe Opérationnelle d’hygiène hospitalière, Centre Hospitalier AndreeRosemon Cayenne, 97300 Cayenne, France
5
Department of Dermatology, Centre Hospitalier Andree Rosemon Cayenne, 97300 Cayenne, France
6
Service des Maladies Infectieuses et Tropicales, Centre Hospitalier AndreeRosemon Cayenne, 97300 Cayenne, France
7
Laboratory, Centre Hospitalier AndreeRosemon Cayenne, 97300 Cayenne, France
8
UMR Tropical Biome and Immunopathology, Université de Guyane, 97300 Cayenne, France
9
Service de Médecine, Centre Hospitalier de l’Ouest Guyanais, 97320 Saint Laurent du Maroni, France
10
Département d’Information Médicale, Centre Hospitalier de l’Ouest Guyanais, 97320 Saint Laurent du Maroni, France
*
Author to whom correspondence should be addressed.
J. Fungi 2020, 6(4), 326; https://doi.org/10.3390/jof6040326
Submission received: 9 November 2020 / Revised: 25 November 2020 / Accepted: 29 November 2020 / Published: 30 November 2020
(This article belongs to the Special Issue Histoplasma and Histoplasmosis 2020)
Browse Figure
Versions Notes

Abstract

Identifying prognostic factors is important in order to guide the choice of first-line therapy for disseminated histoplasmosis. Our objective was to identify factors associated with death among a cohort of 330 patients compiled over 34 years of clinical practice in French Guiana. Survival analysis was performed with death as the failure event and date of symptom onset as the origin event. Incidence rates were and Cox proportional hazards models were computed. Overall, 330 HIV-infected patients with disseminated histoplasmosis were included in the analysis, with 126 deaths occurring. One-quarter of all patients died within 6 months of the first symptoms. Patients with dyspnea, renal failure, arterial blood pressure < 90 mmHG, and a WHO performance score > 2 had a greater incidence of death. Bivariate analyses showed that patients with increased LDH, low hemoglobin, low serum protein, low CD4 counts, and low platelets tended to have a greater incidence of death. After adjusting for potential confounders, patients with dyspnea, a WHO performance score > 2, serum protein < 60 g/L, and hemoglobin < 8.9 g/dL had an increased risk of dying. The interaction terms showed that patients treated with liposomal amphotericin B had a marked reduction in death among patients with renal failure; among renal failure patients, the elevation of LDH was associated with a significant risk of death.
Keywords: disseminated histoplasmosis; HIV; mortality; risk factors; liposomal amphotericin B; French Guiana disseminated histoplasmosis; HIV; mortality; risk factors; liposomal amphotericin B; French Guiana

Share and Cite

MDPI and ACS Style

Nacher, M.; Drak Alsibai, K.; Valdes, A.; Blaizot, R.; Abboud, P.; Demar, M.; Djossou, F.; Epelboin, L.; Misslin, C.; Ntab, B.; et al. Risk Factors for Mortality among HIV-Infected Patients with Disseminated Histoplasmosis. J. Fungi 2020, 6, 326. https://doi.org/10.3390/jof6040326

AMA Style

Nacher M, Drak Alsibai K, Valdes A, Blaizot R, Abboud P, Demar M, Djossou F, Epelboin L, Misslin C, Ntab B, et al. Risk Factors for Mortality among HIV-Infected Patients with Disseminated Histoplasmosis. Journal of Fungi. 2020; 6(4):326. https://doi.org/10.3390/jof6040326

Chicago/Turabian Style

Nacher, Mathieu, Kinan Drak Alsibai, Audrey Valdes, Romain Blaizot, Philippe Abboud, Magalie Demar, Félix Djossou, Loïc Epelboin, Caroline Misslin, Balthazar Ntab, and et al. 2020. "Risk Factors for Mortality among HIV-Infected Patients with Disseminated Histoplasmosis" Journal of Fungi 6, no. 4: 326. https://doi.org/10.3390/jof6040326

APA Style

Nacher, M., Drak Alsibai, K., Valdes, A., Blaizot, R., Abboud, P., Demar, M., Djossou, F., Epelboin, L., Misslin, C., Ntab, B., Adenis, A., & Couppié, P. (2020). Risk Factors for Mortality among HIV-Infected Patients with Disseminated Histoplasmosis. Journal of Fungi, 6(4), 326. https://doi.org/10.3390/jof6040326

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop