Antibiotic Activity of a Paraphaeosphaeria sporulosa-Produced Diketopiperazine against Salmonella enterica
Abstract
:1. Introduction
2. Materials and Methods
2.1. Fungal Isolation and Morphological Characterization
2.2. Molecular Characterization and Phylogenetic Analysis
2.3. Liquid Culture and Metabolite Production
2.4. Antibiotic Assay of Organic Extract
2.5. Extraction and Isolation of Secondary Metabolites
2.6. LC–MS Analysis
2.7. Antibiotic Assay on Fractions and Pure Compound
3. Results
3.1. Morphological and Molecular Characterization of the Fungal Isolate
3.2. Isolation and Chemical Characterization of Bioactive Compound 1
3.3. Antibiotic Activity
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Carrieri, R.; Borriello, G.; Piccirillo, G.; Lahoz, E.; Sorrentino, R.; Cermola, M.; Censi, S.B.; Grauso, L.; Mangoni, A.; Vinale, F. Antibiotic Activity of a Paraphaeosphaeria sporulosa-Produced Diketopiperazine against Salmonella enterica. J. Fungi 2020, 6, 83. https://doi.org/10.3390/jof6020083
Carrieri R, Borriello G, Piccirillo G, Lahoz E, Sorrentino R, Cermola M, Censi SB, Grauso L, Mangoni A, Vinale F. Antibiotic Activity of a Paraphaeosphaeria sporulosa-Produced Diketopiperazine against Salmonella enterica. Journal of Fungi. 2020; 6(2):83. https://doi.org/10.3390/jof6020083
Chicago/Turabian StyleCarrieri, Raffaele, Giorgia Borriello, Giulio Piccirillo, Ernesto Lahoz, Roberto Sorrentino, Michele Cermola, Sergio Bolletti Censi, Laura Grauso, Alfonso Mangoni, and Francesco Vinale. 2020. "Antibiotic Activity of a Paraphaeosphaeria sporulosa-Produced Diketopiperazine against Salmonella enterica" Journal of Fungi 6, no. 2: 83. https://doi.org/10.3390/jof6020083