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Central Nervous System Infections Due to Aspergillus and Other Hyaline Molds
Open AccessCommunication

Antifungal Drugs: Special Problems Treating Central Nervous System Infections

Duke Center for Antimicrobial Stewardship and Infection Prevention, Duke University School of Medicine, Durham, NC 27710, USA
J. Fungi 2019, 5(4), 97; https://doi.org/10.3390/jof5040097
Received: 3 September 2019 / Revised: 29 September 2019 / Accepted: 30 September 2019 / Published: 11 October 2019
(This article belongs to the Special Issue Fungal Infections of the Central Nervous System)
Treating fungal infections in the central nervous system (CNS) remains a challenge despite the availability of new antifungal agents. Therapy is limited by poor understanding of the kinetic properties of antifungal drugs in the CNS compounded by lack of data for many agents. In some cases, clinical response rates do not correspond to data on drug concentrations in the cerebral spinal fluid and/or brain parenchyma. In order to better characterize the use of antifungal agents in treating CNS infections, a review of the essential principles of neuroPK are reviewed. Specific data regarding antifungal drug concentrations in the cerebral spinal fluid and brain tissue are described from human data where available. Alternative dosing regimens and the role of antifungal drug concentration monitoring in treating fungal infections in the CNS are also discussed. Having a better understanding of these key concepts will help guide clinicians in determining the best treatment courses for patients with these devastating infections. View Full-Text
Keywords: antifungal; central nervous system; CSF antifungal; central nervous system; CSF
MDPI and ACS Style

Ashley, E.D. Antifungal Drugs: Special Problems Treating Central Nervous System Infections. J. Fungi 2019, 5, 97.

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