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Central Nervous System Infections Due to Aspergillus and Other Hyaline Molds

Division of Infectious Diseases, University of Michigan Health System, Ann Arbor, MI 48109, USA
J. Fungi 2019, 5(3), 79;
Received: 28 June 2019 / Revised: 23 August 2019 / Accepted: 27 August 2019 / Published: 30 August 2019
(This article belongs to the Special Issue Fungal Infections of the Central Nervous System)
Central nervous system infections due to Aspergillus spp and other hyaline molds such as Fusarium and Scedosporium spp are rare but fatal conditions. Invasion of the central nervous system (CNS) tends to occur as a result of hematogenous dissemination among immunocompromised patients, and by local extension or direct inoculation secondary to trauma in immunocompetent hosts. Efforts should be directed to confirm the diagnosis by image-guided stereotactic brain biopsy when feasible. Non-culture methods could be useful to support the diagnosis, but they have not been validated to be performed in cerebral spinal fluid. Treatment of these infections is challenging given the variable susceptibility profile of these pathogens and the penetration of antifungal agents into the brain. View Full-Text
Keywords: central nervous system; Aspergillus; hyaline molds central nervous system; Aspergillus; hyaline molds
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Miceli, M.H. Central Nervous System Infections Due to Aspergillus and Other Hyaline Molds. J. Fungi 2019, 5, 79.

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