Central Nervous System Infections Due to Aspergillus and Other Hyaline Molds
Abstract
1. Introduction
2. Aspergillus Species
2.1. Pathogenesis
2.2. Clinical Presentation and Outcome
2.3. Diagnosis
2.4. Treatment
3. Other Hyaline Molds
3.1. Fusarium Species
3.2. Scedosporium Species
Funding
Conflicts of Interest
References
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Antifungal Agent | Molecular Mass | Protein Binding | CSF Concentration * | Comment |
---|---|---|---|---|
Voriconazole | 349 Daltons | 58% | ~50% | Small moderately lipophilic molecule |
Posaconazole | 708 Daltons | >98% | Very low to undetectable | Largest lipophilic compound, limited data |
Itraconazole | 705 Daltons | 99.8% | <10% | Lipophilic compound |
Isavuconazole | 437 Daltons | >99% | Low | Water soluble. High concentration in eyes and brain |
Amphotericin B and lipid formulations | 924 Daltons | 90% | Poor in adults; 40–90% in neonates Limited data with lipid formulations | Large molecule with a hydrophilic polydroxyl chain and a lipophilic polyene hydrocarbon chain, poorly soluble in water |
Echinocandins | 1140–1292 Daltons | 97–99% | Negligible | Brain tissue concentration may increase with dose escalation and prolonged exposure |
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Miceli, M.H. Central Nervous System Infections Due to Aspergillus and Other Hyaline Molds. J. Fungi 2019, 5, 79. https://doi.org/10.3390/jof5030079
Miceli MH. Central Nervous System Infections Due to Aspergillus and Other Hyaline Molds. Journal of Fungi. 2019; 5(3):79. https://doi.org/10.3390/jof5030079
Chicago/Turabian StyleMiceli, Marisa H. 2019. "Central Nervous System Infections Due to Aspergillus and Other Hyaline Molds" Journal of Fungi 5, no. 3: 79. https://doi.org/10.3390/jof5030079
APA StyleMiceli, M. H. (2019). Central Nervous System Infections Due to Aspergillus and Other Hyaline Molds. Journal of Fungi, 5(3), 79. https://doi.org/10.3390/jof5030079