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Open AccessArticle

Long-Chain Acyl-CoA Synthetase is Associated with the Growth of Malassezia spp.

School of Life Science and Technology, Tokyo Institute of Technology, J3-7, 4259 Nagatsuta, Midori-ku, Yokohama, Kanagawa 226-8501, Japan
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J. Fungi 2019, 5(4), 88; https://doi.org/10.3390/jof5040088
Received: 14 July 2019 / Revised: 4 September 2019 / Accepted: 9 September 2019 / Published: 21 September 2019
The lipophilic fungal pathogen Malassezia spp. must acquire long-chain fatty acids (LCFAs) from outside the cell. To clarify the mechanism of LCFA acquisition, we investigated fatty acid uptake by this fungus and identified the long-chain acyl-CoA synthetase (ACS) gene FAA1 in three Malassezia spp.: M. globosa, M. pachydermatis, and M. sympodialis. These FAA1 genes could compensate for the double mutation of FAA1 and FAA4 in Saccharomyces cerevisiae, suggesting that Malassezia Faa1 protein recognizes exogenous LCFAs. MgFaa1p and MpFaa1p utilized a medium-chain fatty acid, lauric acid (C12:0). Interestingly, the ACS inhibitor, triacsin C, affected the activity of the Malassezia Faa1 proteins but not that of S. cerevisiae. Triacsin C also reduced the growth of M. globosa, M. pachydermatis, and M. sympodialis. These results suggest that triacsin C and its derivatives are potential compounds for the development of new anti-Malassezia drugs. View Full-Text
Keywords: Malassezia; acyl-CoA synthetase; fatty acid uptake Malassezia; acyl-CoA synthetase; fatty acid uptake
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Tenagy; Tejima, K.; Chen, X.; Iwatani, S.; Kajiwara, S. Long-Chain Acyl-CoA Synthetase is Associated with the Growth of Malassezia spp.. J. Fungi 2019, 5, 88.

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