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Review
Peer-Review Record

Central Nervous System Infections Due to Coccidioidomycosis

J. Fungi 2019, 5(3), 54; https://doi.org/10.3390/jof5030054
by Niki R. Jackson 1, Janis E. Blair 1 and Neil M. Ampel 1,2,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
J. Fungi 2019, 5(3), 54; https://doi.org/10.3390/jof5030054
Submission received: 31 May 2019 / Revised: 20 June 2019 / Accepted: 26 June 2019 / Published: 28 June 2019
(This article belongs to the Special Issue Fungal Infections of the Central Nervous System)

Round 1

Reviewer 1 Report

Well written review of the topic. My only suggestion is a final summary paragraph.

Author Response

A summary paragraph has been added to the manuscript.

Reviewer 2 Report

A very well written review of an important topic. 

The review includes current/state-of-the-art data on this topic and provides detailed guidance for healthcare professionals caring for patients with this challenging infection.

Consider adding the following data to the paper-

-The role of trending CF titers in serum among these patients.

-Timing of placement of VP shunt among those with hydrocephalus; should a period of antifungal therapy be given prior to placement, etc.

-Use of gamma interferon or other treatment options for salvage therapy

-Timing for use of immunosuppressive agents for those with co-existing conditions (autoimmune diseases needing TNF blockers, etc).

Excellent review overall.

Author Response

We have added statements regarding the use of trending serum coccidioidal serology, the controversy regarding when a CSF shunt should be placed, the use of immunosuppressives, and the use of interferon-gamma.

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