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J. Fungi 2018, 4(4), 137; https://doi.org/10.3390/jof4040137

Immunomodulation as a Therapy for Aspergillus Infection: Current Status and Future Perspectives

Department of Internal Medicine II, University Hospital Wuerzburg, WÜ4i, Building C11, 97080 Wuerzburg, Germany
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Received: 15 November 2018 / Revised: 9 December 2018 / Accepted: 10 December 2018 / Published: 14 December 2018
(This article belongs to the Special Issue Fungal Infections in Immunocompromised Hosts)
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Abstract

Invasive aspergillosis (IA) is the most serious life-threatening infectious complication of intensive remission induction chemotherapy and allogeneic stem cell transplantation in patients with a variety of hematological malignancies. Aspergillus fumigatus is the most commonly isolated species from cases of IA. Despite the various improvements that have been made with preventative strategies and the development of antifungal drugs, there is an urgent need for new therapeutic approaches that focus on strategies to boost the host’s immune response, since immunological recovery is recognized as being the major determinant of the outcome of IA. Here, we aim to summarize current knowledge about a broad variety of immunotherapeutic approaches against IA, including therapies based on the transfer of distinct immune cell populations, and the administration of cytokines and antibodies. View Full-Text
Keywords: Immunotherapy; invasive aspergillosis; Aspergillus fumigatus; fungal infections; innate immunity; adaptive immunity; cell therapy; cytokine therapy Immunotherapy; invasive aspergillosis; Aspergillus fumigatus; fungal infections; innate immunity; adaptive immunity; cell therapy; cytokine therapy
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Lauruschkat, C.D.; Einsele, H.; Loeffler, J. Immunomodulation as a Therapy for Aspergillus Infection: Current Status and Future Perspectives. J. Fungi 2018, 4, 137.

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