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J. Fungi 2018, 4(4), 123; https://doi.org/10.3390/jof4040123

Caenorhabditis elegans as a Model Host to Monitor the Candida Infection Processes

Worcester Polytechnic Institute, Worcester, MA 01609, USA
These authors contribute equally to this paper.
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Received: 6 October 2018 / Revised: 31 October 2018 / Accepted: 1 November 2018 / Published: 7 November 2018
(This article belongs to the Special Issue Alternative Models for the Study of Fungal Host-Pathogen Interactions)
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Abstract

C. elegans has several advantages as an experimental host for the study of infectious diseases. Worms are easily maintained and propagated on bacterial lawns. The worms can be frozen for long term storage and still maintain viability years later. Their short generation time and large brood size of thousands of worms grown on a single petri dish, makes it relatively easy to maintain at a low cost. The typical wild type adult worm grows to approximately 1.5 mm in length and are transparent, allowing for the identification of several internal organs using an affordable dissecting microscope. A large collection of loss of function mutant strains are readily available from the C. elegans genetic stock center, making targeted genetic studies in the nematode possible. Here we describe ways in which this facile model host has been used to study Candida albicans, an opportunistic fungal pathogen that poses a serious public health threat. View Full-Text
Keywords: Candida albicans; virulence factors; innate immunity; infectious disease; host-pathogen interactions; model host Candida albicans; virulence factors; innate immunity; infectious disease; host-pathogen interactions; model host
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Elkabti, A.B.; Issi, L.; Rao, R.P. Caenorhabditis elegans as a Model Host to Monitor the Candida Infection Processes. J. Fungi 2018, 4, 123.

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