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What We Do Not Know about Fungal Cell Adhesion Molecules
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Adhesins in Candida glabrata

KU Leuven, Laboratory of Molecular Cell Biology, Kasteelpark Arenberg 31 bus 2438, 3001 Leuven, Belgium
VIB-KU Leuven Center for Microbiology, 3001 Leuven, Belgium
IPICYT, División de Biología Molecular, Camino a la Presa San José 2055, C.P., San Luis Potosí 78216 San Luis Potosí, Mexico
Author to whom correspondence should be addressed.
J. Fungi 2018, 4(2), 60;
Received: 2 May 2018 / Revised: 15 May 2018 / Accepted: 17 May 2018 / Published: 20 May 2018
(This article belongs to the Special Issue Cell Adhesion in Fungal Life and Pathogenesis)
The human fungal pathogen Candida glabrata is causing more and more problems in hospitals, as this species shows an intrinsic antifungal drug resistance or rapidly becomes resistant when challenged with antifungals. C. glabrata only grows in the yeast form, so it is lacking a yeast-to-hyphae switch, which is one of the main virulence factors of C. albicans. An important virulence factor of C. glabrata is its capacity to strongly adhere to many different substrates. To achieve this, C. glabrata expresses a large number of adhesin-encoding genes and genome comparisons with closely related species, including the non-pathogenic S. cerevisiae, which revealed a correlation between the number of adhesin-encoding genes and pathogenicity. The adhesins are involved in the first steps during an infection; they are the first point of contact with the host. For several of these adhesins, their importance in adherence to different substrates and subsequent biofilm formation was demonstrated in vitro or in vivo. In this review, we provide an overview of the role of C. glabrata adhesins during adhesion and biofilm formation both, under in vitro and in vivo conditions. View Full-Text
Keywords: Candida glabrata; adhesin; adhesion; biofilm Candida glabrata; adhesin; adhesion; biofilm
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Timmermans, B.; De Las Peñas, A.; Castaño, I.; Van Dijck, P. Adhesins in Candida glabrata. J. Fungi 2018, 4, 60.

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