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Mechanisms of Pulmonary Escape and Dissemination by Cryptococcus neoformans

Division of Microbiology and Immunology, Department of Pathology, University of Utah, 15 N Medical Drive, Salt Lake City, UT 84112, USA
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J. Fungi 2018, 4(1), 25; https://doi.org/10.3390/jof4010025
Received: 31 January 2018 / Revised: 9 February 2018 / Accepted: 16 February 2018 / Published: 17 February 2018
(This article belongs to the Special Issue Cryptococcus and Cryptococcosis)
Cryptococcus neoformans is a common environmental saprophyte and human fungal pathogen that primarily causes disease in immunocompromised individuals. Similar to many environmentally acquired human fungal pathogens, C. neoformans initiates infection in the lungs. However, the main driver of mortality is invasive cryptococcosis leading to fungal meningitis. After C. neoformans gains a foothold in the lungs, a critical early step in invasion is transversal of the respiratory epithelium. In this review, we summarize current knowledge relating to pulmonary escape. We focus on fungal factors that allow C. neoformans to disseminate from the lungs via intracellular and extracellular routes. View Full-Text
Keywords: Cryptococcus; pulmonary; macrophages; intracellular proliferation; epithelial cells; dissemination; disease progression; capsule; GXM; cell morphology Cryptococcus; pulmonary; macrophages; intracellular proliferation; epithelial cells; dissemination; disease progression; capsule; GXM; cell morphology
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Denham, S.T.; Brown, J.C.S. Mechanisms of Pulmonary Escape and Dissemination by Cryptococcus neoformans. J. Fungi 2018, 4, 25.

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