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Candida albicans Hyphae: From Growth Initiation to Invasion

Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA
J. Fungi 2018, 4(1), 10; https://doi.org/10.3390/jof4010010
Received: 13 December 2017 / Revised: 28 December 2017 / Accepted: 10 January 2018 / Published: 11 January 2018
(This article belongs to the Special Issue Candida and Candidiasis)
Candida albicans is a commensal resident of the human gastrointestinal and genital tracts. Under conditions such as dysbiosis, host immune perturbances, or the presence of catheters/implanted medical devices, the fungus may cause debilitating mucosal or fatal systemic infections. The ability of C. albicans to grow as long filamentous hyphae is critical for its pathogenic potential as it allows the fungus to invade the underlying substratum. In this brief review, I will outline the current understanding regarding the mechanistic regulation of hyphal growth and invasion in C. albicans. View Full-Text
Keywords: Candida albicans; hyphae; invasion Candida albicans; hyphae; invasion
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Desai, J.V. Candida albicans Hyphae: From Growth Initiation to Invasion. J. Fungi 2018, 4, 10.

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