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The Role of Non-Coding RNA in Congenital Heart Diseases

Cardiovascular Development Group, Department of Experimental Biology, University of Jaen, 23071 Jaen, Spain
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J. Cardiovasc. Dev. Dis. 2019, 6(2), 15; https://doi.org/10.3390/jcdd6020015
Received: 26 February 2019 / Revised: 24 March 2019 / Accepted: 26 March 2019 / Published: 1 April 2019
(This article belongs to the Special Issue Non Coding RNAs in the Cardiovascular System)
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Abstract

Cardiovascular development is a complex developmental process starting with the formation of an early straight heart tube, followed by a rightward looping and the configuration of atrial and ventricular chambers. The subsequent step allows the separation of these cardiac chambers leading to the formation of a four-chambered organ. Impairment in any of these developmental processes invariably leads to cardiac defects. Importantly, our understanding of the developmental defects causing cardiac congenital heart diseases has largely increased over the last decades. The advent of the molecular era allowed to bridge morphogenetic with genetic defects and therefore our current understanding of the transcriptional regulation of cardiac morphogenesis has enormously increased. Moreover, the impact of environmental agents to genetic cascades has been demonstrated as well as of novel genomic mechanisms modulating gene regulation such as post-transcriptional regulatory mechanisms. Among post-transcriptional regulatory mechanisms, non-coding RNAs, including therein microRNAs and lncRNAs, are emerging to play pivotal roles. In this review, we summarize current knowledge on the functional role of non-coding RNAs in distinct congenital heart diseases, with particular emphasis on microRNAs and long non-coding RNAs. View Full-Text
Keywords: non-coding RNA; microRNAs; lncRNAs; congenital heart disease non-coding RNA; microRNAs; lncRNAs; congenital heart disease
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Dueñas, A.; Expósito, A.; Aranega, A.; Franco, D. The Role of Non-Coding RNA in Congenital Heart Diseases. J. Cardiovasc. Dev. Dis. 2019, 6, 15.

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