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Communication

Seroprevalence of Immunoglobulin G Antibodies Against Mycobacterium avium subsp. paratuberculosis in Dogs Bred in Japan

by 1,*, 2 and 3
1
Laboratory of Immunology, School Life and Environmental Science, Azabu University, Kanagawa 252-5201, Japan
2
Department of Neurology, School of Medicine, Juntendo University, Tokyo 113-8431, Japan
3
Comparative Medical Research Institute, Ibaraki 305-0856, Japan
*
Author to whom correspondence should be addressed.
Vet. Sci. 2020, 7(3), 93; https://doi.org/10.3390/vetsci7030093
Received: 27 May 2020 / Revised: 11 July 2020 / Accepted: 13 July 2020 / Published: 17 July 2020
(This article belongs to the Special Issue Mycobacterial Infections in Livestock, Companion, and Wild Animals)
In this study, the seroprevalence of immunoglobulin G (IgG) antibodies against Mycobacterium avium subsp. paratuberculosis (MAP) in dogs bred in Japan was evaluated. Ninety-two non-clinical samples were obtained from three institutes and fifty-seven clinical samples were obtained from a veterinary hospital in Japan. Serum titers of total IgG, IgG1 and IgG2 isotype antibodies against MAP were measured using an indirect enzyme-linked immunosorbent assay (ELISA). The IgG antibodies against MAP in non-clinical serum obtained from three institutes was observed to be 2.4%, 20% and 9.0%. Similarly, the IgG1 antibodies titers against MAP were observed to be 7%, 20% and 0%. Lastly, the IgG2 antibodies against MAP were observed to be 7%, 20% and 4.4%. No significance differences in these titers were observed among the three institutes. The IgG, IgG1 and IgG2 antibodies in serum obtained from a veterinary hospital were observed to be 55.3%, 42% and 42%, respectively. Significant differences were found between the non-clinical and clinical samples. The titers in the clinical samples showed a high degree of variance, whereas low variance was found in the non-clinical samples. The IgG antibody levels were thought to be induced following exposure to MAP-contaminated feed. The difference in titers between the clinical and non-clinical samples is likely to be related to the amount of MAP antigen contamination in dog foods. View Full-Text
Keywords: MAP; dogs; IgG antibody; Johne’s disease MAP; dogs; IgG antibody; Johne’s disease
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MDPI and ACS Style

Kuribayashi, T.; Cossu, D.; Momotani, E. Seroprevalence of Immunoglobulin G Antibodies Against Mycobacterium avium subsp. paratuberculosis in Dogs Bred in Japan. Vet. Sci. 2020, 7, 93. https://doi.org/10.3390/vetsci7030093

AMA Style

Kuribayashi T, Cossu D, Momotani E. Seroprevalence of Immunoglobulin G Antibodies Against Mycobacterium avium subsp. paratuberculosis in Dogs Bred in Japan. Veterinary Sciences. 2020; 7(3):93. https://doi.org/10.3390/vetsci7030093

Chicago/Turabian Style

Kuribayashi, Takashi, Davide Cossu, and Eiichi Momotani. 2020. "Seroprevalence of Immunoglobulin G Antibodies Against Mycobacterium avium subsp. paratuberculosis in Dogs Bred in Japan" Veterinary Sciences 7, no. 3: 93. https://doi.org/10.3390/vetsci7030093

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