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Case Report

Atypical Multibacterial Granulomatous Myositis in a Horse: First Report in Italy

1
Department of Veterinary Science, University of Messina, Polo Universitario dell’Annunziata, 98168 Messina (ME), Italy
2
School of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93/95, 62024 Matelica (MC), Italy
3
Department of Pathology and Animal Health, University of Naples “Federico II”, Via Federico Delpino 1, 80137 Napoli, Italy
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Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil
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Institute of Biology, Federal University of Bahia, Salvador-Bahia 40170-115, Brazil
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Institute of Health Sciences, Federal University of Bahia, Salvador-Bahia 40170-115, Brazil
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School of Veterinary, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil
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Scaravet Equine Breeding Center, Via Don Minzoni, 29, 89124 Reggio Calabria, Italy
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Molecular Biology Department, Experimental Zooprophylactic Institute (IZS) of Sicily, Via Gino Marinuzzi 3, 90129 Palermo (PA), Italy
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Department of Veterinary Medicine and Epidemiology, University of California, Davis, CA 95616, USA
*
Author to whom correspondence should be addressed.
The Authors contributed equally.
Vet. Sci. 2020, 7(2), 47; https://doi.org/10.3390/vetsci7020047
Received: 21 March 2020 / Revised: 7 April 2020 / Accepted: 17 April 2020 / Published: 21 April 2020
Infectious causes of myositis are reported relatively uncommonly in horses. Among them, bacterial causes include Streptococcus equi subsp. zooepidemicus, Actinobacillus equuli, Fusobacterium spp. Staphylococcus spp, and Corynebacterium pseudotuberculosis. Infection can be spread to muscles via haematogenous or extension from skin lesions. Parasitic myositis has also been documented. In this report, a 12 year-old Italian Quarter Horse mare presented with diffuse subcutaneous nodules and masses ranging from 2 × 3 to 5 × 20 cm in size, and adherent to subcutis and muscles that were first macroscopically and cytologically diagnosed as pyogranulomas. Subsequently, histological, molecular, bacteriological, and biochemical investigations were performed. All the data obtained allowed to diagnose a severe and diffuse multibacterial granulomatous myositis caused by Corynebacterium pseudotuberculosis and Corynebacterium amycolatum. Following the therapy and an initial disappearance of most of the lesions together with a general improvement of the mare, the clinical condition deteriorated, and new nodules appeared. Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) and PCR techniques revealed the presence of bacteria as Glutamicibacter creatinolyticus and Dietzia spp. To the authors’ knowledge, this case report represents the first description of multibacterial granulomatous myositis due to Corynebacterium pseudotuberculosis, Corynebacterium amycolatum, Glutamicibacter creatinolyticus, and Dietzia spp. in a horse reared in Italy. View Full-Text
Keywords: bacterial myositis; horses; Corynebacterium pseudotuberculosis; Glutamicibacter creatinolyticus; Dietzia spp. bacterial myositis; horses; Corynebacterium pseudotuberculosis; Glutamicibacter creatinolyticus; Dietzia spp.
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MDPI and ACS Style

Rifici, C.; Attili, A.-R.; De Biase, D.; Gonçalves dos Santos, R.; Seyffert, N.; De Paula Castro, T.L.; Pereira Figueiredo, H.C.; Scaramozzino, C.; Reale, S.; Paciello, O.; Cuteri, V.; Spier, S.J.; Azevedo, V.; Mazzullo, G. Atypical Multibacterial Granulomatous Myositis in a Horse: First Report in Italy. Vet. Sci. 2020, 7, 47. https://doi.org/10.3390/vetsci7020047

AMA Style

Rifici C, Attili A-R, De Biase D, Gonçalves dos Santos R, Seyffert N, De Paula Castro TL, Pereira Figueiredo HC, Scaramozzino C, Reale S, Paciello O, Cuteri V, Spier SJ, Azevedo V, Mazzullo G. Atypical Multibacterial Granulomatous Myositis in a Horse: First Report in Italy. Veterinary Sciences. 2020; 7(2):47. https://doi.org/10.3390/vetsci7020047

Chicago/Turabian Style

Rifici, Claudia, Anna-Rita Attili, Davide De Biase, Roselane Gonçalves dos Santos, Núbia Seyffert, Thiago L. De Paula Castro, Henrique C. Pereira Figueiredo, Carmelo Scaramozzino, Stefano Reale, Orlando Paciello, Vincenzo Cuteri, Sharon J. Spier, Vasco Azevedo, and Giuseppe Mazzullo. 2020. "Atypical Multibacterial Granulomatous Myositis in a Horse: First Report in Italy" Veterinary Sciences 7, no. 2: 47. https://doi.org/10.3390/vetsci7020047

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