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Open AccessArticle

Efficacy of a Commercial PCV2a Vaccine with a Two-Dose Regimen Against PCV2d

1
Department of Microbiological Sciences, North Dakota State University, Fargo, ND 58102, USA
2
Animal Disease Research and Diagnostic Laboratory, South Dakota State University, Brookings, SD 57006, USA
3
Veterinary Diagnostic Laboratory, North Dakota State University, Fargo, ND 58102, USA
*
Author to whom correspondence should be addressed.
Vet. Sci. 2019, 6(3), 61; https://doi.org/10.3390/vetsci6030061
Received: 8 May 2019 / Revised: 22 June 2019 / Accepted: 26 June 2019 / Published: 28 June 2019
Porcine circovirus type 2, the causative agent of porcine circovirus associated diseases (PCVAD), consists of three major genotypes PCV2a, 2b and 2d. Current commercial vaccines contain the first-identified PCV2a’s capsid protein or whole virions. Outbreaks of PCVAD, caused by the recently identified PCV2d in vaccinated herds have raised concerns regarding the efficacy of current PCV2a vaccines against PCV2d. Thus, the primary objective of this study was to assess the efficacy of a two-dose regimen for the recently reformulated Fostera PCV MetaStim vaccine, to determine if reformulation with the squalene oil adjuvant and two-dose regimen improves the threshold of protection enough to eliminate viremia in a vaccination and challenge model. Two groups of seven pigs each were vaccinated with the commercial vaccine or PBS, and challenged with the PCV2d virus. Strong pre-challenge virus neutralizing responses were detected against all three genotypes. Post-challenge viremia was not completely eliminated as expected but a 2 log10 mean reduction in viral load was achieved in vaccinated pigs. Vaccinated pigs had a mean score of 0 for pathological evaluation, while unvaccinated pigs had a score of 6.6. In conclusion, the reformulated Fostera PCV MetaStim PCV2a-based vaccine provided significant heterologous protection and was effective against PCV2d. View Full-Text
Keywords: vaccines; PCV2d; antibody; PCV2a; ELISA; viremia; pathology vaccines; PCV2d; antibody; PCV2a; ELISA; viremia; pathology
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Kolyvushko, O.; Rakibuzzaman, A.; Pillatzki, A.; Webb, B.; Ramamoorthy, S. Efficacy of a Commercial PCV2a Vaccine with a Two-Dose Regimen Against PCV2d. Vet. Sci. 2019, 6, 61.

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