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Case Report

Long-Term Survival of a Cat with Primary Leiomyosarcoma of the Urinary Bladder

Veterinary Oncology Specialization Course, Instituto Bioethicus, Botucatu SP 18605-545, Brazil
Superintendencia Unidade Hospitalar Veterinaria Universitaria, Federal University of the Fronteira Sul, Realeza PR 85770-000, Brazil
Department of Veterinary Surgery and Anesthesiology, School of Veterinary Medicine and Animal Science, University of Sao Paulo State – UNESP, Botucatu SP 18618-681, Brazil
Author to whom correspondence should be addressed.
Vet. Sci. 2019, 6(3), 60;
Received: 7 May 2019 / Revised: 18 June 2019 / Accepted: 26 June 2019 / Published: 27 June 2019
Primary bladder leiomyosarcoma was diagnosed in a four-year-old, mixed-breed, spayed female cat that presented with lethargy, stranguria, polyuria, hematuria, urinary incontinence and abdominal sensitivity. On abdominal ultrasound, the urinary bladder was observed to have a preserved anatomical position and a hyperechoic mass. The mass measured approximately 1.5 cm, was irregular, and arose from the mucosa of the bladder wall. Due to the evidence of a primary tumor in the urinary bladder, we conducted a partial cystectomy with a 1.0 cm surgical margin and performed histopathology and immunohistochemistry. The histopathology revealed a poorly differentiated malignant neoplasm, characterized by the proliferation of spindle cells with moderate nuclear pleomorphism, suggestive of leiomyosarcoma. Immunohistochemistry confirmed the histopathological diagnosis, showing positive staining for vimentin, desmin and alpha-smooth muscle actin and negative staining for S100, pan-cytokeratin and MyoD1. We also assessed the proliferative index by Ki67 staining and found that 57% of the neoplastic cells were positive for Ki67. We conducted clinical follow-ups every three months in the first year and every six months thereafter. The patient showed no signs of recurrence after 48 months. The surgery was sufficient to treat the leiomyosarcoma, and adjuvant chemotherapy was not necessary in this case. View Full-Text
Keywords: leiomyosarcoma; urinary bladder; cat leiomyosarcoma; urinary bladder; cat
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MDPI and ACS Style

Buzatto, A.B.; Elias, F.; Franzoni, M.S.; Fonseca-Alves, C.E. Long-Term Survival of a Cat with Primary Leiomyosarcoma of the Urinary Bladder. Vet. Sci. 2019, 6, 60.

AMA Style

Buzatto AB, Elias F, Franzoni MS, Fonseca-Alves CE. Long-Term Survival of a Cat with Primary Leiomyosarcoma of the Urinary Bladder. Veterinary Sciences. 2019; 6(3):60.

Chicago/Turabian Style

Buzatto, Anneliese B., Fabiana Elias, Mayara S. Franzoni, and Carlos E. Fonseca-Alves 2019. "Long-Term Survival of a Cat with Primary Leiomyosarcoma of the Urinary Bladder" Veterinary Sciences 6, no. 3: 60.

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