Next Article in Journal
Gliomatosis Cerebri in the Brain of a Cat
Next Article in Special Issue
Anaplasma phagocytophilum Manipulates Host Cell Apoptosis by Different Mechanisms to Establish Infection
Previous Article in Journal
The Comparative Diagnostic Features of Canine and Human Lymphoma
Open AccessReview

Travelling between Two Worlds: Complement as a Gatekeeper for an Expanded Host Range of Lyme Disease Spirochetes

Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt, Paul-Ehrlich-Str. 40, D-60596 Frankfurt, Germany
Academic Editor: Ulrike Munderloh
Vet. Sci. 2016, 3(2), 12; https://doi.org/10.3390/vetsci3020012
Received: 9 May 2016 / Revised: 3 June 2016 / Accepted: 6 June 2016 / Published: 14 June 2016
(This article belongs to the Special Issue Comparative Studies in Tick-Borne Diseases in Animals and Humans)
Evading innate immunity is a prerequisite for pathogenic microorganisms in order to survive in their respective hosts. Concerning Lyme disease spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato group, a broad range of diverse vertebrates serve as reservoir or even as incidental hosts, including humans. The capability to infect multiple hosts implies that spirochetes have developed sophisticated means to counter the destructive effects of complement of humans and various animals. While the means by which spirochetes overcome the hosts immune defense are far from being completely understood, there is a growing body of evidence suggesting that binding of the key regulator of the alternative pathway, Factor H, plays a pivotal role for immune evasion and that Factor H is an important determinant of host specificity. This review covers (i) the contribution of complement in host-specificity and transmissibility of Lyme disease spirochetes; (ii) the involvement of borrelial-derived determinants to host specificity; (iii) the interplay of human and animal Factor H with complement-acquiring surface proteins of diverse borrelial species; and (iv) the potential role of additional animal complement proteins in the immune evasion of spirochetes. View Full-Text
Keywords: Borrelia; spirochetes; Lyme disease; vertebrates; animal host; human; complement; immune evasion; innate immunity Borrelia; spirochetes; Lyme disease; vertebrates; animal host; human; complement; immune evasion; innate immunity
Show Figures

Figure 1

MDPI and ACS Style

Kraiczy, P. Travelling between Two Worlds: Complement as a Gatekeeper for an Expanded Host Range of Lyme Disease Spirochetes. Vet. Sci. 2016, 3, 12.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop