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Vet. Sci. 2016, 3(2), 11;

The Comparative Diagnostic Features of Canine and Human Lymphoma

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55455, USA
Department of Microbiology, Immunology, and Pathology and the Flint Animal Cancer Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
Author to whom correspondence should be addressed.
Academic Editors: Duncan C. Ferguson and Margarethe Hoenig
Received: 28 April 2016 / Revised: 25 May 2016 / Accepted: 27 May 2016 / Published: 9 June 2016
(This article belongs to the Special Issue Comparative Pathogenesis of Cancers in Animals and Humans)
PDF [11638 KB, uploaded 9 June 2016]


The non-Hodgkin lymphomas (NHLs) are a heterogeneous family of lymphoid malignancies that are among the most common neoplasms of both dogs and humans. Owing to shared molecular, signaling, incidence, and pathologic features, there is a strong framework supporting the utilization of canine lymphoma as a comparative, large animal model of human NHL. In alignment with the biologic similarities, the current approach towards the diagnosis and classification of canine lymphoma is based upon the human World Health Organization guidelines. While this approach has contributed to an increasing appreciation of the potential biological scope of canine lymphoma, it has also become apparent that the most appropriate diagnostic philosophy must be multimodal, namely by requiring knowledge of microscopic, immunophenotypic, and clinical features before establishing a final disease diagnosis. This review seeks to illustrate the comparative similarities and differences in the diagnosis of canine lymphoma through the presentation of the microscopic and immunophenotypic features of its most common forms. View Full-Text
Keywords: lymphoma; comparative oncology; canine; non-Hodgkin lymphoma; comparative pathology lymphoma; comparative oncology; canine; non-Hodgkin lymphoma; comparative pathology

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Seelig, D.M.; Avery, A.C.; Ehrhart, E.J.; Linden, M.A. The Comparative Diagnostic Features of Canine and Human Lymphoma. Vet. Sci. 2016, 3, 11.

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