Next Article in Journal
Detection of Methicillin-Resistant Staphylococci Isolated from Food Producing Animals: A Public Health Implication
Previous Article in Journal
Travelling between Two Worlds: Complement as a Gatekeeper for an Expanded Host Range of Lyme Disease Spirochetes
Case Report

Gliomatosis Cerebri in the Brain of a Cat

Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
Author to whom correspondence should be addressed.
Academic Editors: Duncan C. Ferguson and Margarethe Hoenig
Vet. Sci. 2016, 3(3), 13;
Received: 19 April 2016 / Revised: 16 June 2016 / Accepted: 22 June 2016 / Published: 27 June 2016
An eight-year-old, neutered, female, long-haired cat was presented with a three-week history of progressive lethargy, unlocalized pain in the cervical and lumbar spine, and unwillingness to move. An MRI (magnetic resonance imaging) of the brain revealed poorly circumscribed regions of non-contrast-enhancing heterogeneous T2 hyperintensity within the ventral forebrain and midbrain. A mass effect and evidence of increased intracranial pressure, including transtentorial herniation of the midbrain and herniation of the cerebellar vermis through the foramen magnum, were also observed. Due to progressive clinical decline and MRI results, the cat was humanely euthanized. Gross examination of the brain confirmed caudal transtentorial and foramen magnum herniation. The ventral aspect of the forebrain, midbrain, and brainstem were soft and had loss of detail, but lacked a grossly discernible mass. Histopathological examination found a poorly delineated neoplastic mass composed of hyperchromatic cells with indistinct cytoplasm, ovoid to elongate or curved nuclei, and indistinct nucleoli. The cells lacked immunoreactivity for Olig2, GFAP, Iba1, CD3, and Pax5. Based on the cellular morphology, immunolabeling characteristics, and anatomical location, a diagnosis of gliomatosis cerebri was made. Although uncommon, gliomatosis cerebri should be considered as a differential diagnosis in cats with central nervous system disease. View Full-Text
Keywords: cat; gliomatosis cerebri; brain; T2 hyperintensity cat; gliomatosis cerebri; brain; T2 hyperintensity
Show Figures

Figure 1

MDPI and ACS Style

Shrader, S.; Lai, S.; Cline, K.; Moon, R. Gliomatosis Cerebri in the Brain of a Cat. Vet. Sci. 2016, 3, 13.

AMA Style

Shrader S, Lai S, Cline K, Moon R. Gliomatosis Cerebri in the Brain of a Cat. Veterinary Sciences. 2016; 3(3):13.

Chicago/Turabian Style

Shrader, Stephanie, Serene Lai, Kelsey Cline, and Rachel Moon. 2016. "Gliomatosis Cerebri in the Brain of a Cat" Veterinary Sciences 3, no. 3: 13.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop