Next Article in Journal
Metabolite Profiles of Male and Female Humboldt Penguins
Next Article in Special Issue
Efficacy of Antiviral Drugs against Feline Immunodeficiency Virus
Previous Article in Journal
Beta Adrenergic Signaling: A Targetable Regulator of Angiosarcoma and Hemangiosarcoma

Comparative Analysis of Tat-Dependent and Tat-Deficient Natural Lentiviruses

Pathogénèse et Vaccination Lentivirales, PAVAL Lab., Université Joseph Fourier Grenoble 1, Bat. NanoBio2, 570 rue de la Chimie, BP 53, 38041, Grenoble Cedex 9, France
Author to whom correspondence should be addressed.
Academic Editors: Ellen (Liz) Sparger and Jane Sykes
Vet. Sci. 2015, 2(4), 293-348;
Received: 29 June 2015 / Revised: 24 August 2015 / Accepted: 24 August 2015 / Published: 29 September 2015
The emergence of human immunodeficiency virus (HIV) causing acquired immunodeficiency syndrome (AIDS) in infected humans has resulted in a global pandemic that has killed millions. HIV-1 and HIV-2 belong to the lentivirus genus of the Retroviridae family. This genus also includes viruses that infect other vertebrate animals, among them caprine arthritis-encephalitis virus (CAEV) and Maedi-Visna virus (MVV), the prototypes of a heterogeneous group of viruses known as small ruminant lentiviruses (SRLVs), affecting both goat and sheep worldwide. Despite their long host-SRLV natural history, SRLVs were never found to be responsible for immunodeficiency in contrast to primate lentiviruses. SRLVs only replicate productively in monocytes/macrophages in infected animals but not in CD4+ T cells. The focus of this review is to examine and compare the biological and pathological properties of SRLVs as prototypic Tat-independent lentiviruses with HIV-1 as prototypic Tat-dependent lentiviruses. Results from this analysis will help to improve the understanding of why and how these two prototypic lentiviruses evolved in opposite directions in term of virulence and pathogenicity. Results may also help develop new strategies based on the attenuation of SRLVs to control the highly pathogenic HIV-1 in humans. View Full-Text
Keywords: Lentiviruses; HIV; CAEV; pathogenesis; Tat; latency Lentiviruses; HIV; CAEV; pathogenesis; Tat; latency
Show Figures

Figure 1

MDPI and ACS Style

Bose, D.; Gagnon, J.; Chebloune, Y. Comparative Analysis of Tat-Dependent and Tat-Deficient Natural Lentiviruses. Vet. Sci. 2015, 2, 293-348.

AMA Style

Bose D, Gagnon J, Chebloune Y. Comparative Analysis of Tat-Dependent and Tat-Deficient Natural Lentiviruses. Veterinary Sciences. 2015; 2(4):293-348.

Chicago/Turabian Style

Bose, Deepanwita, Jean Gagnon, and Yahia Chebloune. 2015. "Comparative Analysis of Tat-Dependent and Tat-Deficient Natural Lentiviruses" Veterinary Sciences 2, no. 4: 293-348.

Find Other Styles

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop