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Vet. Sci. 2015, 2(2), 97-110;

Experimental Animal Models of Arteriovenous Malformation: A Review

The Australian School of Advanced Medicine, Macquarie University, NSW 2109, Australia
Author to whom correspondence should be addressed.
Academic Editors: Duncan C. Ferguson and Margarethe Hoenig
Received: 20 March 2015 / Revised: 1 June 2015 / Accepted: 10 June 2015 / Published: 19 June 2015
(This article belongs to the Special Issue Animal Models of Disease)
Full-Text   |   PDF [3269 KB, uploaded 19 June 2015]   |  


Arteriovenous malformations (AVMs) are congenital lesions that cause brain haemorrhage in children and young adults. Current treatment modalities include surgery, radiosurgery and embolization. These treatments are generally effective only for small AVMs. Over one third of AVMs cannot be treated safely and effectively with existing options. Several animal models have been developed with the aims of understanding AVM pathophysiology and improving treatment. No animal model perfectly mimics a human AVM. Each model has limitations and advantages. Models contribute to the understanding of AVMs and hopefully to the development of improved therapies. This paper reviews animal models of AVMs and their advantages and disadvantages. View Full-Text
Keywords: cerebral arteriovenous malformations; animal models cerebral arteriovenous malformations; animal models

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Raj, J.A.; Stoodley, M. Experimental Animal Models of Arteriovenous Malformation: A Review. Vet. Sci. 2015, 2, 97-110.

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