Getah Virus: A New Contaminant in Veterinary Vaccines
Simple Summary
Abstract
1. Introduction
2. Evidence of Contamination with GETV in Live PRRSV Vaccines
3. Genomic Comparison Between Vaccine-Contaminated GETV Strains and Other GETV Strains
3.1. Genomic Comparison of GETV-V1 and Other GETV Strains
3.2. Genomic Comparison of BJ0304 and Other GETV Strains
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Strains | GETV-V1 | BJ0304 | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Complete Genome | 5′ UTR | Non-Structural Polyprotein | Structural Polyprotein | 3′ UTR | Complete Genome | 5′ UTR | Non-Structural Polyprotein | Structural Polyprotein | 3′ UTR | |||||
nt | nt | nt | aa | nt | aa | nt | nt | nt | nt | aa | nt | aa | nt | |
MM2021 | 95.2 | 97.4 | 95.4 | 98.7 | 95.1 | 98.1 | 93.5 | 95.3 | 98.7 | 95.5 | 98.5 | 95.2 | 98 | 94.2 |
Sagiyamavirus | 97.1 | 98.7 | 97.4 | 99 | 97 | 98.4 | 94.6 | 97.3 | 100 | 97.6 | 99 | 97 | 98.4 | 95.3 |
M1 | 98 | 98.7 | 98.2 | 99 | 97.9 | 98.8 | 97.2 | 98.2 | 100 | 98.3 | 99 | 98 | 98.8 | 98 |
16-I-676 | 98.8 | 98.7 | 98.9 | 99.4 | 98.8 | 99.6 | 98.2 | 98.9 | 100 | 98.9 | 99.2 | 98.9 | 99.6 | 99 |
15-I-752 | 98.8 | 98.7 | 99 | 99.5 | 98.8 | 99.6 | 98.2 | 98.9 | 100 | 98.9 | 99.3 | 98.9 | 99.6 | 99 |
14-I-605-C2 | 98.8 | 98.7 | 99 | 99.5 | 98.8 | 99.6 | 98 | 98.9 | 100 | 99 | 99.3 | 98.9 | 99.6 | 98.7 |
12IH26 | 98.9 | 98.7 | 99 | 99.6 | 98.9 | 99.6 | 98.2 | 99 | 100 | 99 | 99.4 | 98.9 | 99.6 | 99 |
GETV-GDFS2-2018 | 98.7 | 98.7 | 98.8 | 99.4 | 98.7 | 99.4 | 98.2 | 98.8 | 100 | 98.8 | 99.2 | 98.8 | 99.4 | 99 |
HNJZ-S2 | 98.8 | 98.7 | 98.9 | 99.6 | 98.9 | 99.6 | 98.5 | 98.9 | 100 | 98.9 | 99.4 | 99 | 99.6 | 99.2 |
HNPDS-2 | 98.9 | 98.7 | 99.1 | 99.5 | 98.8 | 99.7 | 98 | 99.1 | 100 | 99.2 | 99.5 | 98.9 | 99.7 | 98.7 |
HNNY-2 | 98.9 | 98.7 | 99.1 | 99.5 | 98.9 | 99.7 | 98.2 | 99.1 | 100 | 99.1 | 99.5 | 99 | 99.7 | 99 |
JL17/08 | 98.9 | 98.7 | 99.1 | 99.5 | 98.9 | 99.6 | 98 | 99 | 100 | 99.1 | 99.4 | 98.9 | 99.6 | 98.7 |
HNJZ-S1 | 98.9 | 98.7 | 99.1 | 99.4 | 98.9 | 99.7 | 98.2 | 99.1 | 100 | 99.1 | 99.2 | 99 | 99.7 | 99 |
SC266 | 98.5 | 98.7 | 98.7 | 99.1 | 98.5 | 99.4 | 97.5 | 98.7 | 100 | 98.7 | 99 | 98.6 | 99.4 | 98.2 |
SC483 | 98.5 | 98.7 | 98.7 | 99.2 | 98.4 | 99.4 | 97.5 | 98.7 | 100 | 98.8 | 99.1 | 98.5 | 99.4 | 98.2 |
SC201807 | 98.7 | 97.4 | 98.9 | 99.5 | 98.7 | 99.6 | 95.5 | 98.8 | 98.7 | 98.9 | 99.4 | 98.8 | 99.6 | 96.2 |
JL1707 | 98.9 | 98.7 | 99.1 | 99.5 | 98.8 | 99.3 | 98.5 | 99.1 | 100 | 99.1 | 99.3 | 98.9 | 99.3 | 99.2 |
HB0234 | 98.9 | 98.7 | 99.1 | 99.3 | 98.8 | 99.3 | 98.5 | 99.1 | 100 | 99.2 | 99.2 | 98.9 | 99.3 | 99.2 |
JS18 | / | / | 99.5 | 99.6 | 99.4 | 99.7 | / | 96.6 | / | 99 | 99.3 | 98.6 | 99.2 | / |
AH9192 | 99.4 | 98.7 | 99.3 | 99.3 | 99.4 | 99.6 | 99.5 | 98.7 | 100 | 98.9 | 99.1 | 98.6 | 99.2 | 98.7 |
GETV-V1 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 99 | 98.7 | 99.1 | 99.3 | 98.9 | 99.5 | 98.2 |
YN12042 | 98.4 | 98.7 | 98.8 | 99.3 | 98.9 | 99.6 | 88.3 | 98.5 | 100 | 98.8 | 99.2 | 99 | 99.7 | 88.6 |
SC1210 | 98.7 | 98.7 | 98.9 | 99.4 | 98.6 | 99.5 | 96.7 | 98.8 | 100 | 98.9 | 99.3 | 98.7 | 99.5 | 97.5 |
YN0540 | 98.8 | 98.7 | 99 | 99.4 | 98.9 | 99.6 | 96.7 | 99 | 100 | 99 | 99.3 | 99 | 99.6 | 97.5 |
South Korea | 98.2 | 98.7 | 99.2 | 99.5 | 99.2 | 99.6 | 70.2 | 98.4 | 100 | 99.3 | 99.4 | 99.3 | 99.8 | 70.6 |
GX201808 | 97.3 | 97.4 | 97.3 | 99 | 97.3 | 99 | 98.5 | 97.5 | 98.7 | 97.4 | 99 | 97.5 | 99 | 98.2 |
HuN1 | 97.5 | 98.7 | 97.4 | 99.2 | 97.8 | 99.2 | 97.7 | 97.7 | 100 | 97.5 | 99.1 | 97.9 | 99.2 | 98 |
SD17/09 | 97.7 | 98.7 | 97.7 | 99.3 | 97.6 | 99.2 | 98.5 | 97.8 | 100 | 97.8 | 99.3 | 97.7 | 99.2 | 98.7 |
JL1808 | 97.7 | 98.7 | 97.8 | 99.3 | 97.7 | 99.3 | 98.2 | 97.9 | 100 | 97.9 | 99.3 | 97.7 | 99.3 | 98.5 |
LEIV 17741 MPR | 98.5 | 98.7 | 98.5 | 99.3 | 98.7 | 99.7 | 98.2 | 98.7 | 100 | 98.6 | 99.2 | 98.8 | 99.7 | 99 |
MI-110-C1 | 98.6 | 98.7 | 98.7 | 99.5 | 98.6 | 99.6 | 98 | 98.7 | 100 | 98.7 | 99.3 | 98.7 | 99.6 | 98.7 |
B254 | / | / | 96.3 | 98.4 | 96.3 | 98.4 | / | / | / | 96.4 | 98.2 | 96.1 | 98 | / |
YN12031 | 96.2 | 97.4 | 96.3 | 98.6 | 96.4 | 98.8 | 95.5 | 96.1 | 98.7 | 96.3 | 98.5 | 96.3 | 98.4 | 96 |
GETV/SW/Thailand/2017 | 96 | 98.7 | 96.3 | 98.8 | 95.8 | 98.6 | 94.7 | 95.9 | 100 | 96.3 | 98.7 | 95.6 | 98.3 | 95.2 |
LEIV 16275 Mag | 97.4 | 97.4 | 97.6 | 99.2 | 97.5 | 99.2 | 96 | 97.4 | 98.7 | 97.7 | 99.1 | 97.6 | 99.2 | 96.7 |
GETV-JX-CHN-22 | 98.6 | 97.4 | 98.8 | 99.5 | 98.7 | 99.5 | 98 | 98.8 | 98.7 | 98.8 | 99.3 | 98.7 | 99.5 | 98.7 |
GETV-YL | 98.7 | 98.7 | 98.9 | 99.5 | 98.8 | 99.7 | 98.2 | 98.8 | 100 | 98.9 | 99.3 | 98.8 | 99.6 | 99 |
GETV-XJ-2019-07 | 98.3 | 98.7 | 98.5 | 99.3 | 98.4 | 99.5 | 97.5 | 98.5 | 100 | 98.5 | 99.2 | 98.4 | 99.5 | 98.2 |
GETV/SCrph328 | / | / | 98.9 | 99.6 | 98.5 | 99.6 | / | / | / | 98.9 | 99.5 | 98.7 | 99.6 | / |
GS11-155 | 98.9 | 98.7 | 99.1 | 99.5 | 98.8 | 99.7 | 98.2 | 99.1 | 100 | 99.2 | 99.4 | 98.9 | 99.7 | 98.5 |
dog202206 | 0 | 98.7 | 98.8 | 99.5 | 98.5 | 99.3 | 0 | 0 | 100 | 98.9 | 99.4 | 98.5 | 99.2 | 0 |
Rbsq202206 | 96 | 98.7 | 96.3 | 98.7 | 95.9 | 98.5 | 94.7 | 95.9 | 100 | 96.4 | 98.6 | 95.7 | 98.2 | 95.2 |
GDQY2022 | 98.8 | 98.7 | 99 | 99.6 | 98.9 | 99.7 | 98 | 98.9 | 100 | 99 | 99.4 | 98.9 | 99.7 | 98.7 |
GDJM2022 | 98.5 | 97.4 | 98.7 | 99.5 | 98.5 | 99.3 | 98.2 | 98.6 | 98.7 | 98.6 | 99.3 | 98.6 | 99.3 | 99 |
SCZY202010 | 98.6 | 98.7 | 98.6 | 99.1 | 98.8 | 99.6 | 97.5 | 98.7 | 100 | 98.7 | 98.9 | 98.8 | 99.6 | 98.2 |
HeN2021 | 98.7 | 98.7 | 98.9 | 99.5 | 98.7 | 99.5 | 98 | 98.9 | 100 | 98.9 | 99.3 | 98.8 | 99.5 | 98.7 |
GD201907-1 | / | / | 97.2 | 98.7 | 97.5 | 99.1 | / | / | / | 97.3 | 98.7 | 97.6 | 99.1 | / |
GX201909 | / | / | 99.4 | 99.6 | 99.4 | 99.7 | 0 | / | / | 98.9 | 99.3 | 98.6 | 99.2 | / |
HeB201707 | / | / | 98.6 | 99 | 98.4 | 99.4 | 97.5 | / | / | 98.6 | 98.9 | 98.5 | 99.4 | 98.2 |
HeN201907 | / | / | 98.8 | 99.5 | 98.7 | 99.6 | 0 | / | / | 98.9 | 99.4 | 98.7 | 99.4 | / |
BJ0304 | 99 | 98.7 | 99.1 | 99.3 | 98.9 | 99.5 | 98.2 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
19-703 | / | / | 98.6 | 99.4 | 98.5 | 99.3 | 0 | / | / | 98.6 | 99.2 | 98.6 | 99.3 | / |
NMDK1813-1 | 98.3 | 98.7 | 98.8 | 99.6 | 98.5 | 99.6 | 85.8 | 98.4 | 100 | 98.9 | 99.5 | 98.7 | 99.6 | 86.5 |
GZ201808 | / | / | 99.4 | 99.5 | 99.4 | 99.6 | / | / | / | 99 | 99.3 | 98.6 | 99.2 | / |
GDHYLC23 | 98.3 | 97.4 | 98.8 | 99.5 | 98.5 | 99.6 | 89.4 | 98.5 | 98.7 | 98.8 | 99.4 | 98.6 | 99.6 | 90 |
GD2202/mosquito/China/2/2022 | 98.9 | 98.7 | 99.1 | 99.6 | 98.8 | 99.6 | 98 | 99 | 100 | 99.1 | 99.3 | 99 | 99.7 | 98.7 |
GETV-GDFS9-2018 | 98.7 | 98.7 | 98.8 | 99.4 | 98.7 | 99.4 | 98.2 | 98.8 | 100 | 98.8 | 99.2 | 98.8 | 99.4 | 99 |
HNPDS-1 | 98.9 | 98.7 | 99.1 | 99.5 | 98.9 | 99.7 | 97.5 | 99.1 | 100 | 99.2 | 99.5 | 98.9 | 99.7 | 98.2 |
HNNY-1 | 98.9 | 98.7 | 74.3 | 74.5 | 98.9 | 99.7 | 98 | 99.1 | 100 | 74.3 | 74.5 | 99 | 99.7 | 98.7 |
15-I-1105 | 98.8 | 98.7 | 98.9 | 99.4 | 98.8 | 99.6 | 98 | 98.9 | 100 | 98.9 | 99.2 | 98.9 | 99.6 | 98.7 |
16-I-674 | 98.8 | 98.7 | 98.9 | 99.4 | 98.8 | 99.6 | 98.2 | 98.9 | 100 | 98.9 | 99.2 | 98.9 | 99.6 | 99 |
16-I-599 | 98.8 | 98.7 | 98.9 | 99.4 | 98.8 | 99.6 | 98 | 98.9 | 100 | 98.9 | 99.2 | 98.9 | 99.6 | 98.7 |
14-I-605-C1 | 98.8 | 98.7 | 99 | 99.5 | 98.8 | 99.6 | 98.2 | 98.9 | 100 | 99 | 99.3 | 98.9 | 99.6 | 99 |
MI-110-C2 | 98.6 | 98.7 | 98.7 | 99.5 | 98.6 | 99.7 | 98 | 98.7 | 100 | 98.7 | 99.4 | 98.7 | 99.7 | 98.7 |
Kochi/01/2005 | 97.8 | 98.7 | 97.9 | 99.3 | 97.8 | 99.3 | 98 | 97.9 | 100 | 97.9 | 99.3 | 97.9 | 99.3 | 98.2 |
SC202010 | 98.4 | 98.7 | 98.6 | 99.1 | 98.4 | 99 | 97.5 | 98.6 | 100 | 98.6 | 98.9 | 98.5 | 99.2 | 98.2 |
GD201909 | / | 98.7 | 99.3 | 99.5 | 99.4 | 99.7 | / | / | 100 | 98.8 | 99.3 | 98.6 | 99.2 | / |
GX202005 | / | / | 97.3 | 98.9 | 97.6 | 98.8 | / | / | / | 97.4 | 98.8 | 97.6 | 98.7 | / |
JS201809-2 | / | / | 98.8 | 99.4 | 98.7 | 99.6 | / | / | / | 98.8 | 99.3 | 98.7 | 99.4 | / |
JX202004 | / | / | 97.2 | 98.9 | 97.4 | 99.1 | 98.5 | / | / | 97.3 | 98.9 | 97.5 | 99.1 | 98.7 |
SX201809 | / | / | 99 | 99.5 | 98.7 | 99.7 | / | / | / | 99 | 99.3 | 98.8 | 99.7 | / |
FJ202005-2 | / | / | 99.4 | 99.5 | 99.1 | 99.1 | / | / | / | 98.9 | 99.3 | 98.2 | 98.6 | / |
HuB201905 | / | / | 99.1 | 99.6 | 98.9 | 99.7 | / | / | / | 99.1 | 99.4 | 99 | 99.7 | / |
SD201910 | / | / | 98.9 | 99.4 | 98.9 | 99.7 | 97.7 | / | / | 98.9 | 99.2 | 99 | 99.7 | 98.5 |
SC202009 | / | / | 98.8 | 99.4 | 98.5 | 99.5 | 97.5 | / | / | 98.8 | 99.3 | 98.6 | 99.6 | 98.2 |
FJ201807-1 | / | / | 99.5 | 99.6 | 99.4 | 99.7 | / | / | / | 99 | 99.3 | 98.6 | 99.2 | / |
HeN202009-2 | 98.8 | 98.7 | 98.9 | 99.5 | 98.9 | 99.7 | 98 | 98.9 | 100 | 98.9 | 99.3 | 98.9 | 99.7 | 98.7 |
GX1 | / | / | 98.9 | 99.5 | 98.7 | 99.6 | / | / | / | 98.9 | 99.4 | 98.7 | 99.4 | / |
GETV/SCrph129/2020 | / | / | 98.8 | 99.5 | 98.5 | 99.6 | / | / | / | 98.8 | 99.4 | 98.6 | 99.6 | / |
NM,JA_F2_18-8L-NH-Cxp-Y-1-1 | 98.6 | 98.7 | 98.8 | 99.5 | 98.4 | 99.6 | 97.5 | 98.8 | 100 | 98.9 | 99.4 | 98.5 | 99.6 | 98.2 |
Getahvirus-1 | 98.2 | 98.7 | 99.2 | 99.5 | 99.2 | 99.6 | 70.2 | 98.4 | 100 | 99.3 | 99.4 | 99.3 | 99.8 | 70.6 |
16-0810-26 | / | / | 99 | 99.4 | 98.8 | 99.6 | / | / | / | 98.9 | 99.2 | 98.9 | 99.6 | / |
GETV-China/GX2020 | / | 96.1 | 95.6 | 98.3 | 95.1 | 98 | / | / | 97.4 | 95.6 | 98.2 | 95 | 97.7 | / |
YN2305/cattle/China/5/2023 | 97.7 | 98.7 | 73.3 | 74.3 | 97.7 | 99.3 | 98.5 | 97.9 | 100 | 73.3 | 74.3 | 97.7 | 99.3 | 98.7 |
JLy1 | 98.8 | 98.7 | 98.9 | 99.4 | 98.7 | 99.3 | 97.2 | 98.9 | 100 | 99 | 99.3 | 98.9 | 99.5 | 98 |
SD2206 | 98.9 | 98.7 | 99.1 | 99.6 | 98.9 | 99.7 | 98 | 99.1 | 100 | 99.1 | 99.4 | 99 | 99.7 | 98.7 |
HN-QH23-As-10 | / | / | 98.6 | 99.4 | 98.3 | 99.4 | / | / | / | 98.6 | 99.3 | 98.3 | 99.4 | / |
HN-QH23-As-12 | / | / | 98.5 | 99.4 | 98.3 | 99.5 | / | / | / | 98.6 | 99.3 | 98.4 | 99.5 | / |
HN-QH23-As-14 | / | / | 98.6 | 99.3 | 98.3 | 99.4 | / | / | / | 98.6 | 99.3 | 98.3 | 99.4 | / |
GETV-JX-CHN-22-P7 | 98.6 | 97.4 | 98.7 | 99.4 | 98.8 | 99.7 | 98 | 98.8 | 98.7 | 98.7 | 99.3 | 98.8 | 99.7 | 98.7 |
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Chu, P.-P.; Chen, S.-N.; Zhou, X.; Wei, Z.-Z.; Zhai, S.-L. Getah Virus: A New Contaminant in Veterinary Vaccines. Vet. Sci. 2025, 12, 82. https://doi.org/10.3390/vetsci12020082
Chu P-P, Chen S-N, Zhou X, Wei Z-Z, Zhai S-L. Getah Virus: A New Contaminant in Veterinary Vaccines. Veterinary Sciences. 2025; 12(2):82. https://doi.org/10.3390/vetsci12020082
Chicago/Turabian StyleChu, Pin-Pin, Sheng-Nan Chen, Xia Zhou, Zu-Zhang Wei, and Shao-Lun Zhai. 2025. "Getah Virus: A New Contaminant in Veterinary Vaccines" Veterinary Sciences 12, no. 2: 82. https://doi.org/10.3390/vetsci12020082
APA StyleChu, P.-P., Chen, S.-N., Zhou, X., Wei, Z.-Z., & Zhai, S.-L. (2025). Getah Virus: A New Contaminant in Veterinary Vaccines. Veterinary Sciences, 12(2), 82. https://doi.org/10.3390/vetsci12020082