Repeated Administration of the Cannabinoid WIN Alters the Isoflurane-Sparing Effect of Morphine and Dexmedetomidine
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Anesthetic Procedure
2.2. Minimum Alveolar Concentration Determination
2.3. Experimental Design
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Group | MAC% | SD | % MAC Increase (↑) or Decrease (↓) | p-Value | 95% CI |
---|---|---|---|---|---|
MAC (ISO) | 1.32 | 0.06 | - | 1.27–1.37 | |
MAC (ISO + CANN) | 1.69 * | 0.09 | ↑ 28% | <0.0001 | 1.61–1.76 |
MAC (ISO + MOR) | 0.97 * | 0.02 | ↓ 26% | <0.0001 | 0.95–0.99 |
MAC (ISO + CANN + MOR) | 1.55 + | 0.08 | ↓ 8% | 0.0094 | 1.47–1.62 |
MAC (ISO + DEX) | 0.68 * | 0.10 | ↓ 48% | <0.0001 | 0.59–0.77 |
MAC (ISO + CANN + DEX) | 0.67 + | 0.08 | ↓ 60% | <0.0001 | 0.60–0.74 |
Value | MAC (ISO) | MAC (ISO + CANN) | MAC (ISO + MOR) | MAC (ISO + CANN + MOR) | MAC (ISO + DEX) | MAC (ISO + CANN + DEX) |
---|---|---|---|---|---|---|
Heart rate (bpm) | 401 ± 8 | 403 ± 7 | 399 ± 8 | 401 ± 11 | 303 ± 16 * | 297 ± 21 + |
MAP (mmHg) | 93 ± 8 | 90 ± 9 | 91 ± 7 | 92 ± 8 | 86 ± 7 | 84 ± 11 |
Temperature °C | 37.7 ± 0.07 | 37.6 ± 0.12 | 37.2 ± 0.11 | 37.4 ± 0.09 | 37.4 ± 0.10 | 37.5 ± 0.08 |
pH | 7.3 ± 03 | 7.3 ± 0.04 | 7.4 ± 0.02 | 7.3 ± 0.02 | 7.3 ± 0.06 | 7.3 ± 0.09 |
PaO2 (mmHg) | 301 ± 34 | 295 ± 8 | 299 ± 12 | 289 ± 10 | 291 ± 16 | 289 ± 13 |
PaCo2 (mmHg) | 37 ± 4 | 37 ± 1 | 38 ± 2 | 38 ± 4 | 32 ± 2 | 37 ± 7 |
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Ibancovichi, J.A.; Chávez-Monteagudo, J.R.; Sánchez-Aparicio, P.; De Paz-Campos, M.A. Repeated Administration of the Cannabinoid WIN Alters the Isoflurane-Sparing Effect of Morphine and Dexmedetomidine. Vet. Sci. 2023, 10, 310. https://doi.org/10.3390/vetsci10050310
Ibancovichi JA, Chávez-Monteagudo JR, Sánchez-Aparicio P, De Paz-Campos MA. Repeated Administration of the Cannabinoid WIN Alters the Isoflurane-Sparing Effect of Morphine and Dexmedetomidine. Veterinary Sciences. 2023; 10(5):310. https://doi.org/10.3390/vetsci10050310
Chicago/Turabian StyleIbancovichi, José Antonio, Julio Raúl Chávez-Monteagudo, Pedro Sánchez-Aparicio, and Marco Antonio De Paz-Campos. 2023. "Repeated Administration of the Cannabinoid WIN Alters the Isoflurane-Sparing Effect of Morphine and Dexmedetomidine" Veterinary Sciences 10, no. 5: 310. https://doi.org/10.3390/vetsci10050310