Local and Systemic Antibody Responses in Beef Calves Vaccinated with a Modified-Live Virus Bovine Respiratory Syncytial Virus (BRSV) Vaccine at Birth following BRSV Infection
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Experimental Design
2.2. Experimental Challenge with BRSV
2.3. Clinical Evaluation and Sample Collection
2.4. BRSV Neutralizing Antibodies in Serum
2.5. Determination of Anti-BRSV IgG-1 and IgA in Nasal Secretions
2.6. Real-Time Reverse Transcription PCR
2.7. Statistical Analysis
3. Results
3.1. Transfer of Passive Immunity and Clinical Outcomes
3.2. BRSV Neutralizing Antibodies in Serum
3.3. BRSV-IgG-1 and IgA Titers in Nasal Secretions
3.4. BRSV Real-Time RT-PCR in Nasal Secretions
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Time Point | BRSV Real Time RT-PCR CT (Median, (IQR)) | p-Value | |
---|---|---|---|
Control | Vacc | ||
Day 0 (Challenge Day) | 0 | 0 | 1.0 |
Day 4 | 32.7 (29.1, 34) | 32.7 (31, 34.3) | 0.85 |
Day 6 | 33.7 (32.2, 34.9) | 34.5 (32.3, 36.2) | 0.13 |
Day 8 | 32.9 (31.1, 34.1) | 33.9 (32.1, 35) | 0.36 |
Day 10 | 36.1 (33.2, 36.9) | 34.9 (33.8, 36.8) | 0.09 |
Day 14 | 0 | 0 | 1.0 |
Day 21 | 0 | 0 | 1.0 |
Day 28 | 0 | 0 | 1.0 |
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Martínez, D.A.; Chamorro, M.F.; Passler, T.; Huber, L.; Walz, P.H.; Thoresen, M.; Raithel, G.; Silvis, S.; Stockler, R.; Woolums, A.R. Local and Systemic Antibody Responses in Beef Calves Vaccinated with a Modified-Live Virus Bovine Respiratory Syncytial Virus (BRSV) Vaccine at Birth following BRSV Infection. Vet. Sci. 2023, 10, 20. https://doi.org/10.3390/vetsci10010020
Martínez DA, Chamorro MF, Passler T, Huber L, Walz PH, Thoresen M, Raithel G, Silvis S, Stockler R, Woolums AR. Local and Systemic Antibody Responses in Beef Calves Vaccinated with a Modified-Live Virus Bovine Respiratory Syncytial Virus (BRSV) Vaccine at Birth following BRSV Infection. Veterinary Sciences. 2023; 10(1):20. https://doi.org/10.3390/vetsci10010020
Chicago/Turabian StyleMartínez, David A., Manuel F. Chamorro, Thomas Passler, Laura Huber, Paul H. Walz, Merrilee Thoresen, Gage Raithel, Scott Silvis, Ricardo Stockler, and Amelia R. Woolums. 2023. "Local and Systemic Antibody Responses in Beef Calves Vaccinated with a Modified-Live Virus Bovine Respiratory Syncytial Virus (BRSV) Vaccine at Birth following BRSV Infection" Veterinary Sciences 10, no. 1: 20. https://doi.org/10.3390/vetsci10010020