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Understanding the Role of Fibroblasts following a 3D Tumoroid Implantation for Breast Tumor Formation

Department of Medical Laboratory Sciences and Public Health, Tarleton State University, a Member of Texas A & M University System, Fort Worth, TX 76104, USA
Academic Editors: Francesco Cappello and Mugurel Constantin Rusu
Bioengineering 2021, 8(11), 163; https://doi.org/10.3390/bioengineering8110163
Received: 29 September 2021 / Revised: 22 October 2021 / Accepted: 24 October 2021 / Published: 27 October 2021
(This article belongs to the Topic Human Anatomy and Pathophysiology)
An understanding of the participation and modulation of fibroblasts during tumor formation and growth is still unclear. Among many speculates, one might be the technical challenge to reveal the versatile function of fibroblasts in tissue complexity, and another is the dynamics in tissue physiology and cell activity. The histology of most solid tumors shows a predominant presence of fibroblasts, suggesting that tumor cells recruit fibroblasts for breast tumor growth. In this review paper, therefore, the migration, activation, differentiation, secretion, and signaling systems that are associated with fibroblasts and cancer-associated fibroblasts (CAFs) after implantation of a breast tumoroid, i.e., a lab-generated tumor tissue into an animal, are discussed. View Full-Text
Keywords: fibroblasts; cancer-associated fibroblasts; tumor growth; tumoroids fibroblasts; cancer-associated fibroblasts; tumor growth; tumoroids
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MDPI and ACS Style

Rijal, G. Understanding the Role of Fibroblasts following a 3D Tumoroid Implantation for Breast Tumor Formation. Bioengineering 2021, 8, 163. https://doi.org/10.3390/bioengineering8110163

AMA Style

Rijal G. Understanding the Role of Fibroblasts following a 3D Tumoroid Implantation for Breast Tumor Formation. Bioengineering. 2021; 8(11):163. https://doi.org/10.3390/bioengineering8110163

Chicago/Turabian Style

Rijal, Girdhari. 2021. "Understanding the Role of Fibroblasts following a 3D Tumoroid Implantation for Breast Tumor Formation" Bioengineering 8, no. 11: 163. https://doi.org/10.3390/bioengineering8110163

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